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Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons

Célia Biane, Florian Rückerl, Therese Abrahamsson, Cécile Saint-Cloment, Jean Mariani, View ORCID ProfileRyuichi Shigemoto, View ORCID ProfileDavid A. DiGregorio, Rachel M. Sherrard, View ORCID ProfileLaurence Cathala
doi: https://doi.org/10.1101/2021.01.06.425658
Célia Biane
1Sorbonne Université et CNRS UMR 8256, Adaptation Biologique et Vieillissement 9 Quai St Bernard, 75005 Paris, France
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Florian Rückerl
3Department of Neuroscience, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France; CNRS URA 21821
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Therese Abrahamsson
3Department of Neuroscience, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France; CNRS URA 21821
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Cécile Saint-Cloment
3Department of Neuroscience, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France; CNRS URA 21821
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Jean Mariani
1Sorbonne Université et CNRS UMR 8256, Adaptation Biologique et Vieillissement 9 Quai St Bernard, 75005 Paris, France
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Ryuichi Shigemoto
4Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria
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David A. DiGregorio
3Department of Neuroscience, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France; CNRS URA 21821
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Rachel M. Sherrard
1Sorbonne Université et CNRS UMR 8256, Adaptation Biologique et Vieillissement 9 Quai St Bernard, 75005 Paris, France
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Laurence Cathala
1Sorbonne Université et CNRS UMR 8256, Adaptation Biologique et Vieillissement 9 Quai St Bernard, 75005 Paris, France
2Paris Brain Institute, CNRS UMR 7225 - Inserm U1127 – Sorbonne UniversitéGroupe Hospitalier Pitié Salpêtrière 47 Boulevard de l’Hôpital 75013 Paris France
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  • ORCID record for Laurence Cathala
  • For correspondence: Laurence.cathala@sorbonne-universite.fr
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Abstract

Synaptic transmission, connectivity, and dendritic morphology mature in parallel during brain development and are often disrupted in neurodevelopmental disorders. Yet how these changes influence the neuronal computations necessary for normal brain function are not well understood. To identify cellular mechanisms underlying the maturation of synaptic integration in interneurons, we combined patch-clamp recordings of excitatory inputs in cerebellar stellate cells (SCs), 3D-reconstruction of SC morphology with excitatory synapse location, and biophysical modeling. We found that, during development, synaptic strength was homogeneously reduced along the somato-dendritic axis, but that dendritic integration was always sublinear. However, dendritic branching increased without changes in synapse density, leading to a substantial gain in distal inputs. Thus, changes in synapse distribution, rather than dendrite cable properties, are the dominant mechanism underlying the maturation of neuronal computation. These mechanisms favor the emergence of a spatially compartmentalized two-stage integration model promoting location-dependent integration within dendritic subunits.

Footnotes

  • Celia Biane: celiabiane1{at}gmail.com, Florian Rückerl: florian.ruckerl{at}pasteur.fr, Therese Abrahamsson: therese.abrahamsson{at}gmail.com Cécile Saint-Cloment: cecile.saint-cloment{at}pasteur.fr, David DiGregorio: david.digregorio{at}pasteur.fr, Ryuichi Shigemoto: ryuichi.shigemoto{at}ist.ac.at, Rachel Sherrard: rachel.sherrard{at}sorbonne-universite.fr, Jean Mariani: jean.mariani{at}sorbonne-universite.fr

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 09, 2021.
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Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons
Célia Biane, Florian Rückerl, Therese Abrahamsson, Cécile Saint-Cloment, Jean Mariani, Ryuichi Shigemoto, David A. DiGregorio, Rachel M. Sherrard, Laurence Cathala
bioRxiv 2021.01.06.425658; doi: https://doi.org/10.1101/2021.01.06.425658
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Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons
Célia Biane, Florian Rückerl, Therese Abrahamsson, Cécile Saint-Cloment, Jean Mariani, Ryuichi Shigemoto, David A. DiGregorio, Rachel M. Sherrard, Laurence Cathala
bioRxiv 2021.01.06.425658; doi: https://doi.org/10.1101/2021.01.06.425658

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