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Understanding the holobiont: crosstalk between gut microbiota and mitochondria during endurance

View ORCID ProfileNúria Mach, Marco Moroldo, Andrea Rau, Jérôme Lecardonnel, Laurence Le Moyec, Céline Robert, View ORCID ProfileEric Barrey
doi: https://doi.org/10.1101/2021.01.08.425889
Núria Mach
1GABI UMR 1313, INRAE, Université Paris-Saclay, AgroParisTech, Jouy-en-Josas, France
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  • For correspondence: nuria.mach@inrae.fr
Marco Moroldo
1GABI UMR 1313, INRAE, Université Paris-Saclay, AgroParisTech, Jouy-en-Josas, France
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Andrea Rau
1GABI UMR 1313, INRAE, Université Paris-Saclay, AgroParisTech, Jouy-en-Josas, France
2BioEcoAgro Joint Research Unit, INRAE, Université de Liège, Université de Lille, Université de Picardie Jules Verne, Estrées-Mons, France
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Jérôme Lecardonnel
1GABI UMR 1313, INRAE, Université Paris-Saclay, AgroParisTech, Jouy-en-Josas, France
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Laurence Le Moyec
3Université d’Évry Val d’Essonne, Université Paris-Saclay, Évry, France
4MCAM UMR7245, CNRS, Muséum National d’Histoire Naturelle, Paris, France
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Céline Robert
1GABI UMR 1313, INRAE, Université Paris-Saclay, AgroParisTech, Jouy-en-Josas, France
5École Nationale Vétérinaire d’Alfort, Maisons-Alfort, France
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Eric Barrey
1GABI UMR 1313, INRAE, Université Paris-Saclay, AgroParisTech, Jouy-en-Josas, France
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ABSTRACT

Endurance exercise has a dramatic impact on the functionality of mitochondria and on the composition of the intestinal microbiome, but the mechanisms regulating the crosstalk between these two components are still largely unknown. Here, we sampled 20 elite horses before and after an endurance race and used blood transcriptome, blood metabolome and fecal microbiome to describe the gut-mitochondria crosstalk. A subset of mitochondria-related differentially expressed genes involved in pathways such as energy metabolism, oxidative stress and inflammation was discovered and then shown to be associated with butyrate-producing bacteria of the Lachnospiraceae family, especially Eubacterium. The mechanisms involved were not fully understood, but through the action of their metabolites likely acted on PPARγ, the FRX-CREB axis and their downstream targets to delay the onset of hypoglycemia, inflammation and extend running time. Our results also suggested that circulating free fatty acids may act not merely as fuel but drive mitochondrial inflammatory responses triggered by the translocation of gut bacterial polysaccharides following endurance. Targeting the gut-mitochondria axis therefore appears to be a potential strategy to enhance athletic performance.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted January 09, 2021.
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Understanding the holobiont: crosstalk between gut microbiota and mitochondria during endurance
Núria Mach, Marco Moroldo, Andrea Rau, Jérôme Lecardonnel, Laurence Le Moyec, Céline Robert, Eric Barrey
bioRxiv 2021.01.08.425889; doi: https://doi.org/10.1101/2021.01.08.425889
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Understanding the holobiont: crosstalk between gut microbiota and mitochondria during endurance
Núria Mach, Marco Moroldo, Andrea Rau, Jérôme Lecardonnel, Laurence Le Moyec, Céline Robert, Eric Barrey
bioRxiv 2021.01.08.425889; doi: https://doi.org/10.1101/2021.01.08.425889

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