Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques

Neeltje van Doremalen; Jyothi N. Purushotham; Jonathan E. Schulz; Myndi G. Holbrook; Trenton Bushmaker; Aaron Carmody; Julia R. Port; Claude K. Yinda; Atsushi Okumura; Greg Saturday; Fatima Amanat; Florian Krammer; Patrick W. Hanley; Brian J. Smith; Jamie Lovaglio; Sarah L. Anzick; Kent Barbian; Craig Martens; Sarah Gilbert; Teresa Lambe; Vincent J. Munster

doi:10.1101/2021.01.09.426058

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Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques

Neeltje van Doremalen, Jyothi N. Purushotham, Jonathan E. Schulz, Myndi G. Holbrook, Trenton Bushmaker, Aaron Carmody, Julia R. Port, Claude K. Yinda, Atsushi Okumura, Greg Saturday, Fatima Amanat, Florian Krammer, Patrick W. Hanley, Brian J. Smith, Jamie Lovaglio, Sarah L. Anzick, Kent Barbian, Craig Martens, View ORCID ProfileSarah Gilbert, Teresa Lambe, View ORCID ProfileVincent J. Munster

doi: https://doi.org/10.1101/2021.01.09.426058

Neeltje van Doremalen

1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

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Jyothi N. Purushotham

1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

2The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK

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Jonathan E. Schulz

1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

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Myndi G. Holbrook

1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

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Trenton Bushmaker

1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

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Aaron Carmody

3Research Technologies Branch, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana, USA

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Julia R. Port

1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

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Claude K. Yinda

1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

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Atsushi Okumura

1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

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Greg Saturday

4Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

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Fatima Amanat

5Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

6Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

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Florian Krammer

5Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

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Patrick W. Hanley

4Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

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Brian J. Smith

4Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

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Jamie Lovaglio

4Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

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Sarah L. Anzick

3Research Technologies Branch, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana, USA

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Kent Barbian

3Research Technologies Branch, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana, USA

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Craig Martens

3Research Technologies Branch, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana, USA

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Sarah Gilbert

2The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK

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ORCID record for Sarah Gilbert

Teresa Lambe

2The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK

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Vincent J. Munster

1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

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ORCID record for Vincent J. Munster
For correspondence: vincent.munster@nih.gov

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