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Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques

Neeltje van Doremalen, Jyothi N. Purushotham, Jonathan E. Schulz, Myndi G. Holbrook, Trenton Bushmaker, Aaron Carmody, Julia R. Port, Claude K. Yinda, Atsushi Okumura, Greg Saturday, Fatima Amanat, Florian Krammer, Patrick W. Hanley, Brian J. Smith, Jamie Lovaglio, Sarah L. Anzick, Kent Barbian, Craig Martens, View ORCID ProfileSarah Gilbert, Teresa Lambe, View ORCID ProfileVincent J. Munster
doi: https://doi.org/10.1101/2021.01.09.426058
Neeltje van Doremalen
1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
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Jyothi N. Purushotham
1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
2The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
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Jonathan E. Schulz
1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
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Myndi G. Holbrook
1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
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Trenton Bushmaker
1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
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Aaron Carmody
3Research Technologies Branch, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana, USA
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Julia R. Port
1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
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Claude K. Yinda
1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
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Atsushi Okumura
1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
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Greg Saturday
4Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
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Fatima Amanat
5Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
6Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
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Florian Krammer
5Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
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Patrick W. Hanley
4Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
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Brian J. Smith
4Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
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Jamie Lovaglio
4Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
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Sarah L. Anzick
3Research Technologies Branch, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana, USA
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Kent Barbian
3Research Technologies Branch, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana, USA
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Craig Martens
3Research Technologies Branch, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana, USA
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Sarah Gilbert
2The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
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  • ORCID record for Sarah Gilbert
Teresa Lambe
2The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
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Vincent J. Munster
1Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
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  • ORCID record for Vincent J. Munster
  • For correspondence: vincent.munster@nih.gov
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Posted January 11, 2021.
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Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques
Neeltje van Doremalen, Jyothi N. Purushotham, Jonathan E. Schulz, Myndi G. Holbrook, Trenton Bushmaker, Aaron Carmody, Julia R. Port, Claude K. Yinda, Atsushi Okumura, Greg Saturday, Fatima Amanat, Florian Krammer, Patrick W. Hanley, Brian J. Smith, Jamie Lovaglio, Sarah L. Anzick, Kent Barbian, Craig Martens, Sarah Gilbert, Teresa Lambe, Vincent J. Munster
bioRxiv 2021.01.09.426058; doi: https://doi.org/10.1101/2021.01.09.426058
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Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques
Neeltje van Doremalen, Jyothi N. Purushotham, Jonathan E. Schulz, Myndi G. Holbrook, Trenton Bushmaker, Aaron Carmody, Julia R. Port, Claude K. Yinda, Atsushi Okumura, Greg Saturday, Fatima Amanat, Florian Krammer, Patrick W. Hanley, Brian J. Smith, Jamie Lovaglio, Sarah L. Anzick, Kent Barbian, Craig Martens, Sarah Gilbert, Teresa Lambe, Vincent J. Munster
bioRxiv 2021.01.09.426058; doi: https://doi.org/10.1101/2021.01.09.426058

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