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Synthesis, Characterization, and Nanodisc formation of Non-ionic Polymers

Thirupathi Ravula, Ayyalusamy Ramamoorthy
doi: https://doi.org/10.1101/2021.01.11.426267
Thirupathi Ravula
Biophysics and Department of Chemistry, Biomedical Engineering, Macromolecular Science and Engineering, The University of Michigan, Ann Arbor, MI 48109-1055, USA
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Ayyalusamy Ramamoorthy
Biophysics and Department of Chemistry, Biomedical Engineering, Macromolecular Science and Engineering, The University of Michigan, Ann Arbor, MI 48109-1055, USA
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  • For correspondence: ramamoor@umich.edu
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ABSTRACT

A family of non-ionic amphiphilic polymers synthesized by hydrophobic functionalization of fructo-oligosaccharides/inulin is reported. We show the stability of lipid-nanodiscs formed by these polymers against pH and divalent metal ions, and their magnetic-alignment properties. The reported results also demonstrate that the non-ionic polymers extract membrane proteins with unprecedented efficiency.

Competing Interest Statement

Authors declare are the inventors of a recently filed related US patent.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted January 11, 2021.
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Synthesis, Characterization, and Nanodisc formation of Non-ionic Polymers
Thirupathi Ravula, Ayyalusamy Ramamoorthy
bioRxiv 2021.01.11.426267; doi: https://doi.org/10.1101/2021.01.11.426267
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Synthesis, Characterization, and Nanodisc formation of Non-ionic Polymers
Thirupathi Ravula, Ayyalusamy Ramamoorthy
bioRxiv 2021.01.11.426267; doi: https://doi.org/10.1101/2021.01.11.426267

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