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Low generalizability of polygenic scores in African populations due to genetic and environmental diversity
Lerato Majara, Allan Kalungi, Nastassja Koen, Heather Zar, Dan J. Stein, Eugene Kinyanda, Elizabeth G. Atkinson, View ORCID ProfileAlicia R. Martin
doi: https://doi.org/10.1101/2021.01.12.426453
Lerato Majara
1Global Initiative for Neuropsychiatric Genetics Education in Research (GINGER), Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA
2MRC Human Genetics Research Unit, Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
Allan Kalungi
1Global Initiative for Neuropsychiatric Genetics Education in Research (GINGER), Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA
3Department of Psychiatry, College of Health Sciences, Makerere University, Kampala, Uganda
4Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
5Mental Health Project, Medical Research Council/Uganda Virus Research Institute (MRC/UVRI) & London School of Hygiene and Tropical Medicine (LSHTM), Uganda Research Unit, Entebbe, Uganda
Nastassja Koen
1Global Initiative for Neuropsychiatric Genetics Education in Research (GINGER), Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA
6Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa
7South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, Cape Town, South Africa
Heather Zar
8Department of Paediatrics and Child Health, Red Cross Children’s Hospital and Medical Research Council Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
Dan J. Stein
6Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa
7South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, Cape Town, South Africa
Eugene Kinyanda
5Mental Health Project, Medical Research Council/Uganda Virus Research Institute (MRC/UVRI) & London School of Hygiene and Tropical Medicine (LSHTM), Uganda Research Unit, Entebbe, Uganda
Elizabeth G. Atkinson
9Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA
10Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
11Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Alicia R. Martin
9Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA
10Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
11Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Posted January 14, 2021.
Low generalizability of polygenic scores in African populations due to genetic and environmental diversity
Lerato Majara, Allan Kalungi, Nastassja Koen, Heather Zar, Dan J. Stein, Eugene Kinyanda, Elizabeth G. Atkinson, Alicia R. Martin
bioRxiv 2021.01.12.426453; doi: https://doi.org/10.1101/2021.01.12.426453
Low generalizability of polygenic scores in African populations due to genetic and environmental diversity
Lerato Majara, Allan Kalungi, Nastassja Koen, Heather Zar, Dan J. Stein, Eugene Kinyanda, Elizabeth G. Atkinson, Alicia R. Martin
bioRxiv 2021.01.12.426453; doi: https://doi.org/10.1101/2021.01.12.426453
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