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N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2
Matthew McCallum, Anna De Marco, Florian Lempp, M. Alejandra Tortorici, Dora Pinto, Alexandra C. Walls, Martina Beltramello, Alex Chen, Zhuoming Liu, Fabrizia Zatta, Samantha Zepeda, Julia di Iulio, John E. Bowen, Martin Montiel-Ruiz, Jiayi Zhou, Laura E. Rosen, Siro Bianchi, Barbara Guarino, Chiara Silacci Fregni, Rana Abdelnabi, Shi-Yan Caroline Foo, Paul W. Rothlauf, Louis-Marie Bloyet, Fabio Benigni, Elisabetta Cameroni, Johan Neyts, Agostino Riva, Gyorgy Snell, Amalio Telenti, Sean P.J. Whelan, Herbert W. Virgin, Davide Corti, Matteo Samuele Pizzuto, View ORCID ProfileDavid Veesler
doi: https://doi.org/10.1101/2021.01.14.426475
Matthew McCallum
1Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
Anna De Marco
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
Florian Lempp
3Vir Biotechnology, San Francisco, CA 94158, USA
M. Alejandra Tortorici
1Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
Dora Pinto
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
Alexandra C. Walls
1Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
Martina Beltramello
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
Alex Chen
3Vir Biotechnology, San Francisco, CA 94158, USA
Zhuoming Liu
4Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA
Fabrizia Zatta
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
Samantha Zepeda
1Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
Julia di Iulio
3Vir Biotechnology, San Francisco, CA 94158, USA
John E. Bowen
1Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
Martin Montiel-Ruiz
3Vir Biotechnology, San Francisco, CA 94158, USA
Jiayi Zhou
3Vir Biotechnology, San Francisco, CA 94158, USA
Laura E. Rosen
3Vir Biotechnology, San Francisco, CA 94158, USA
Siro Bianchi
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
Barbara Guarino
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
Chiara Silacci Fregni
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
Rana Abdelnabi
5Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Belgium
Shi-Yan Caroline Foo
5Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Belgium
Paul W. Rothlauf
4Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA
Louis-Marie Bloyet
4Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA
Fabio Benigni
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
Elisabetta Cameroni
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
Johan Neyts
5Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Belgium
Agostino Riva
6III Division of Infectious Diseases, Luigi Sacco Hospital, University of Milan, 20157 Milan, Italy
Gyorgy Snell
3Vir Biotechnology, San Francisco, CA 94158, USA
Amalio Telenti
3Vir Biotechnology, San Francisco, CA 94158, USA
Sean P.J. Whelan
4Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA
Herbert W. Virgin
3Vir Biotechnology, San Francisco, CA 94158, USA
Davide Corti
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
Matteo Samuele Pizzuto
2Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland
David Veesler
1Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
Posted January 14, 2021.
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2
Matthew McCallum, Anna De Marco, Florian Lempp, M. Alejandra Tortorici, Dora Pinto, Alexandra C. Walls, Martina Beltramello, Alex Chen, Zhuoming Liu, Fabrizia Zatta, Samantha Zepeda, Julia di Iulio, John E. Bowen, Martin Montiel-Ruiz, Jiayi Zhou, Laura E. Rosen, Siro Bianchi, Barbara Guarino, Chiara Silacci Fregni, Rana Abdelnabi, Shi-Yan Caroline Foo, Paul W. Rothlauf, Louis-Marie Bloyet, Fabio Benigni, Elisabetta Cameroni, Johan Neyts, Agostino Riva, Gyorgy Snell, Amalio Telenti, Sean P.J. Whelan, Herbert W. Virgin, Davide Corti, Matteo Samuele Pizzuto, David Veesler
bioRxiv 2021.01.14.426475; doi: https://doi.org/10.1101/2021.01.14.426475
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2
Matthew McCallum, Anna De Marco, Florian Lempp, M. Alejandra Tortorici, Dora Pinto, Alexandra C. Walls, Martina Beltramello, Alex Chen, Zhuoming Liu, Fabrizia Zatta, Samantha Zepeda, Julia di Iulio, John E. Bowen, Martin Montiel-Ruiz, Jiayi Zhou, Laura E. Rosen, Siro Bianchi, Barbara Guarino, Chiara Silacci Fregni, Rana Abdelnabi, Shi-Yan Caroline Foo, Paul W. Rothlauf, Louis-Marie Bloyet, Fabio Benigni, Elisabetta Cameroni, Johan Neyts, Agostino Riva, Gyorgy Snell, Amalio Telenti, Sean P.J. Whelan, Herbert W. Virgin, Davide Corti, Matteo Samuele Pizzuto, David Veesler
bioRxiv 2021.01.14.426475; doi: https://doi.org/10.1101/2021.01.14.426475
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