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Autism Spectrum Disorder is a Risk Factor for PTSD-like Memory Formation

View ORCID ProfileA.S. Al Abed, A. Sellami, View ORCID ProfileA. Marighetto, View ORCID ProfileA. Desmedt, View ORCID ProfileN. Dehorter
doi: https://doi.org/10.1101/2021.01.18.427217
A.S. Al Abed
1Eccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
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  • For correspondence: shaam.alabed@anu.edu.au
A. Sellami
2Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215, INSERM, F-33000 Bordeaux, France
3Université de Bordeaux, F-33000 Bordeaux, France
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A. Marighetto
2Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215, INSERM, F-33000 Bordeaux, France
3Université de Bordeaux, F-33000 Bordeaux, France
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A. Desmedt
2Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215, INSERM, F-33000 Bordeaux, France
3Université de Bordeaux, F-33000 Bordeaux, France
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N. Dehorter
1Eccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
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ABSTRACT

The predisposition of Autism Spectrum Disorder (ASD) to Post-Traumatic Stress Disorder (PTSD) remained to be established. Here, we show that exposure to a single mild stressful event induces maladaptive memory, which recapitulates all features of PTSD, and is associated with the broad dysfunction of the prefrontal-hippocampo-amygdalar network. Using optogenetics, we demonstrate that prefrontal cortex hyperactivation triggers this PTSD-like memory. Finally, we show that recontextualization of the traumatic event normalizes maladaptive memory in ASD conditions. Overall, this study provides the first direct demonstration that ASD represents a risk factor for PTSD and uncovers new mechanisms that underlie pathological memory formation.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 19, 2021.
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Autism Spectrum Disorder is a Risk Factor for PTSD-like Memory Formation
A.S. Al Abed, A. Sellami, A. Marighetto, A. Desmedt, N. Dehorter
bioRxiv 2021.01.18.427217; doi: https://doi.org/10.1101/2021.01.18.427217
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Autism Spectrum Disorder is a Risk Factor for PTSD-like Memory Formation
A.S. Al Abed, A. Sellami, A. Marighetto, A. Desmedt, N. Dehorter
bioRxiv 2021.01.18.427217; doi: https://doi.org/10.1101/2021.01.18.427217

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