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BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2
Ruilin Tian, Avi J. Samelson, Veronica V. Rezelj, Merissa Chen, Gokul N. Ramadoss, Xiaoyan Guo, Alice Mac Kain, Quang Dinh Tran, View ORCID ProfileShion A. Lim, Irene Lui, James Nunez, Sarah J. Rockwood, Na Liu, View ORCID ProfileJared Carlson-Stevermer, View ORCID ProfileJennifer Oki, View ORCID ProfileTravis Maures, View ORCID ProfileKevin Holden, Jonathan S. Weissman, James A. Wells, Bruce Conklin, Marco Vignuzzi, View ORCID ProfileMartin Kampmann
doi: https://doi.org/10.1101/2021.01.19.427194
Ruilin Tian
1Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
2Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA
3School of Medicine, Southern University of Science and Technology, Shenzhen, China 518055
Avi J. Samelson
1Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
2Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA
Veronica V. Rezelj
4Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75015 Paris, France
Merissa Chen
1Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
2Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA
Gokul N. Ramadoss
5Gladstone Institutes, San Francisco, 94158, CA, USA
6Biomedical Sciences PhD Program, University of California, San Francisco, CA, USA
Xiaoyan Guo
1Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
2Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA
Alice Mac Kain
4Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75015 Paris, France
7École Doctorale BioSPC, Université de Paris, Sorbonne Paris Cité, 75006 Paris, France
Quang Dinh Tran
4Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75015 Paris, France
7École Doctorale BioSPC, Université de Paris, Sorbonne Paris Cité, 75006 Paris, France
Shion A. Lim
8Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA
9Department of Antibody Engineering, Genentech Inc., South San Francisco, CA, 94080, USA
Irene Lui
8Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA
James Nunez
10Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
11Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA
Sarah J. Rockwood
5Gladstone Institutes, San Francisco, 94158, CA, USA
Na Liu
3School of Medicine, Southern University of Science and Technology, Shenzhen, China 518055
Jared Carlson-Stevermer
12Synthego Corporation, Redwood City, CA 94063, USA
Jennifer Oki
12Synthego Corporation, Redwood City, CA 94063, USA
Travis Maures
12Synthego Corporation, Redwood City, CA 94063, USA
Kevin Holden
12Synthego Corporation, Redwood City, CA 94063, USA
Jonathan S. Weissman
10Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
11Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA
13Whitehead Institute for Biomedical Research, Cambridge, 02142, USA
James A. Wells
2Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA
8Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA
10Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
Bruce Conklin
5Gladstone Institutes, San Francisco, 94158, CA, USA
15Innovative Genomics Institute, Berkeley, 94720, CA, USA
16Department of Ophthalmology, University of California, San Francisco, San Francisco, CA. 94158, USA
17Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA
Marco Vignuzzi
4Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75015 Paris, France
Martin Kampmann
1Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
2Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA
18Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, 94158, USA
Article usage
Posted January 19, 2021.
BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2
Ruilin Tian, Avi J. Samelson, Veronica V. Rezelj, Merissa Chen, Gokul N. Ramadoss, Xiaoyan Guo, Alice Mac Kain, Quang Dinh Tran, Shion A. Lim, Irene Lui, James Nunez, Sarah J. Rockwood, Na Liu, Jared Carlson-Stevermer, Jennifer Oki, Travis Maures, Kevin Holden, Jonathan S. Weissman, James A. Wells, Bruce Conklin, Marco Vignuzzi, Martin Kampmann
bioRxiv 2021.01.19.427194; doi: https://doi.org/10.1101/2021.01.19.427194
BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2
Ruilin Tian, Avi J. Samelson, Veronica V. Rezelj, Merissa Chen, Gokul N. Ramadoss, Xiaoyan Guo, Alice Mac Kain, Quang Dinh Tran, Shion A. Lim, Irene Lui, James Nunez, Sarah J. Rockwood, Na Liu, Jared Carlson-Stevermer, Jennifer Oki, Travis Maures, Kevin Holden, Jonathan S. Weissman, James A. Wells, Bruce Conklin, Marco Vignuzzi, Martin Kampmann
bioRxiv 2021.01.19.427194; doi: https://doi.org/10.1101/2021.01.19.427194
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