Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

Naveenchandra Suryadevara; Swathi Shrihari; Pavlo Gilchuk; Laura A. VanBlargan; Elad Binshtein; Seth J. Zost; Rachel S. Nargi; Rachel E. Sutton; Emma S. Winkler; Elaine C. Chen; Mallorie E. Fouch; Edgar Davidson; Benjamin J. Doranz; Robert H. Carnahan; Larissa B. Thackray; Michael S. Diamond; James E. Crowe

doi:10.1101/2021.01.19.427324

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Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

Naveenchandra Suryadevara, Swathi Shrihari, Pavlo Gilchuk, Laura A. VanBlargan, Elad Binshtein, Seth J. Zost, Rachel S. Nargi, Rachel E. Sutton, Emma S. Winkler, Elaine C. Chen, Mallorie E. Fouch, Edgar Davidson, Benjamin J. Doranz, View ORCID ProfileRobert H. Carnahan, Larissa B. Thackray, Michael S. Diamond, James E. Crowe Jr.

doi: https://doi.org/10.1101/2021.01.19.427324

Naveenchandra Suryadevara

1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

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Swathi Shrihari

4Department of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110 USA

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Pavlo Gilchuk

1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

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Laura A. VanBlargan

4Department of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110 USA

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Elad Binshtein

1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

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Seth J. Zost

1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

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Rachel S. Nargi

1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

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Rachel E. Sutton

1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

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Emma S. Winkler

3Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, 63110, USA

4Department of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110 USA

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Elaine C. Chen

5Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

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Mallorie E. Fouch

6Integral Molecular, Philadelphia, PA, 19104, USA

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Edgar Davidson

6Integral Molecular, Philadelphia, PA, 19104, USA

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Benjamin J. Doranz

6Integral Molecular, Philadelphia, PA, 19104, USA

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Robert H. Carnahan

1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

7Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

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ORCID record for Robert H. Carnahan

Larissa B. Thackray

4Department of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110 USA

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For correspondence: james.crowe@vumc.org

Michael S. Diamond

2Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO, 63110, USA

3Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, 63110, USA

4Department of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110 USA

8Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO, 63110, USA

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For correspondence: james.crowe@vumc.org

James E. Crowe Jr.

1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

5Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

7Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

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For correspondence: james.crowe@vumc.org

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Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

Naveenchandra Suryadevara, Swathi Shrihari, Pavlo Gilchuk, Laura A. VanBlargan, Elad Binshtein, Seth J. Zost, Rachel S. Nargi, Rachel E. Sutton, Emma S. Winkler, Elaine C. Chen, Mallorie E. Fouch, Edgar Davidson, Benjamin J. Doranz, Robert H. Carnahan, Larissa B. Thackray, Michael S. Diamond, James E. Crowe Jr.

bioRxiv 2021.01.19.427324; doi: https://doi.org/10.1101/2021.01.19.427324

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Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

Naveenchandra Suryadevara, Swathi Shrihari, Pavlo Gilchuk, Laura A. VanBlargan, Elad Binshtein, Seth J. Zost, Rachel S. Nargi, Rachel E. Sutton, Emma S. Winkler, Elaine C. Chen, Mallorie E. Fouch, Edgar Davidson, Benjamin J. Doranz, Robert H. Carnahan, Larissa B. Thackray, Michael S. Diamond, James E. Crowe Jr.

bioRxiv 2021.01.19.427324; doi: https://doi.org/10.1101/2021.01.19.427324

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