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Survey of peridomestic mammal susceptibility to SARS-CoV-2 infection

View ORCID ProfileAngela M. Bosco-Lauth, J. Jeffrey Root, Stephanie M. Porter, Audrey E. Walker, Lauren Guilbert, Daphne Hawvermale, Aimee Pepper, Rachel M. Maison, Airn E. Hartwig, Paul Gordy, Helle Bielefeldt-Ohmann, Richard A. Bowen
doi: https://doi.org/10.1101/2021.01.21.427629
Angela M. Bosco-Lauth
1Colorado State University, Fort Collins, Colorado, USA
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  • For correspondence: angela.bosco-lauth@colostate.edu
J. Jeffrey Root
2U.S. Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado, USA
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Stephanie M. Porter
1Colorado State University, Fort Collins, Colorado, USA
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Audrey E. Walker
1Colorado State University, Fort Collins, Colorado, USA
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Lauren Guilbert
1Colorado State University, Fort Collins, Colorado, USA
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Daphne Hawvermale
1Colorado State University, Fort Collins, Colorado, USA
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Aimee Pepper
1Colorado State University, Fort Collins, Colorado, USA
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Rachel M. Maison
1Colorado State University, Fort Collins, Colorado, USA
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Airn E. Hartwig
1Colorado State University, Fort Collins, Colorado, USA
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Paul Gordy
1Colorado State University, Fort Collins, Colorado, USA
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Helle Bielefeldt-Ohmann
3School of Chemistry & Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland. St Lucia, Queensland, Australia
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Richard A. Bowen
1Colorado State University, Fort Collins, Colorado, USA
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Abstract

Wild animals have been implicated as the origin of SARS-CoV-2, but it is largely unknown how the virus affects most wildlife species and if wildlife could ultimately serve as a reservoir for maintaining the virus outside the human population. Here we show that several common peridomestic species, including deer mice, bushy-tailed woodrats, and striped skunks, are susceptible to infection and can shed the virus in respiratory secretions. In contrast, we demonstrate that cottontail rabbits, fox squirrels, Wyoming ground squirrels, black-tailed prairie dogs, house mice, and racoons are not susceptible to SARS-CoV-2 infection. Our work expands upon the existing knowledge base of susceptible species and provides evidence that human-wildlife interactions could result in continued transmission of SARS-CoV-2.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 21, 2021.
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Survey of peridomestic mammal susceptibility to SARS-CoV-2 infection
Angela M. Bosco-Lauth, J. Jeffrey Root, Stephanie M. Porter, Audrey E. Walker, Lauren Guilbert, Daphne Hawvermale, Aimee Pepper, Rachel M. Maison, Airn E. Hartwig, Paul Gordy, Helle Bielefeldt-Ohmann, Richard A. Bowen
bioRxiv 2021.01.21.427629; doi: https://doi.org/10.1101/2021.01.21.427629
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Survey of peridomestic mammal susceptibility to SARS-CoV-2 infection
Angela M. Bosco-Lauth, J. Jeffrey Root, Stephanie M. Porter, Audrey E. Walker, Lauren Guilbert, Daphne Hawvermale, Aimee Pepper, Rachel M. Maison, Airn E. Hartwig, Paul Gordy, Helle Bielefeldt-Ohmann, Richard A. Bowen
bioRxiv 2021.01.21.427629; doi: https://doi.org/10.1101/2021.01.21.427629

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