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Circuit organization of the excitatory sensorimotor loop through hand/forelimb S1 and M1

Naoki Yamawaki, Martinna G. Raineri Tapies, Austin M. Stults, Gregory A. Smith, Gordon M. G. Shepherd
doi: https://doi.org/10.1101/2021.01.22.427843
Naoki Yamawaki
1Departments of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA, 60611
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Martinna G. Raineri Tapies
1Departments of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA, 60611
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Austin M. Stults
2Departments of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA, 60611
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Gregory A. Smith
2Departments of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA, 60611
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Gordon M. G. Shepherd
1Departments of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA, 60611
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  • For correspondence: g-shepherd@northwestern.edu
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Abstract

Sensory-guided limb control relies on communication across sensorimotor loops. For active touch with the hand, the longest loop is the transcortical continuation of ascending pathways, particularly the lemnisco-cortical and corticocortical pathways carrying tactile signals via the cuneate nucleus, ventral posterior lateral (VPL) thalamus, and primary somatosensory (S1) and motor (M1) cortices to reach corticospinal neurons and influence descending activity. We characterized excitatory connectivity along this pathway in the mouse. In the lemnisco-cortical leg, disynaptic cuneate→VPL→S1 connections excited mainly layer (L) 4 neurons. In the corticocortical leg, S1→M1 connections from L2/3 and L5A neurons mainly excited downstream L2/3 neurons, which excite corticospinal neurons. The findings provide a detailed new wiring diagram for the hand/forelimb-related transcortical circuit, delineating a basic but complex set of cell-type-specific feedforward excitatory connections that selectively and extensively engage diverse intratelencephalic projection neurons, thereby polysynaptically linking subcortical somatosensory input to cortical motor output to spinal cord.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 24, 2021.
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Circuit organization of the excitatory sensorimotor loop through hand/forelimb S1 and M1
Naoki Yamawaki, Martinna G. Raineri Tapies, Austin M. Stults, Gregory A. Smith, Gordon M. G. Shepherd
bioRxiv 2021.01.22.427843; doi: https://doi.org/10.1101/2021.01.22.427843
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Circuit organization of the excitatory sensorimotor loop through hand/forelimb S1 and M1
Naoki Yamawaki, Martinna G. Raineri Tapies, Austin M. Stults, Gregory A. Smith, Gordon M. G. Shepherd
bioRxiv 2021.01.22.427843; doi: https://doi.org/10.1101/2021.01.22.427843

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