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Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides

Bing Wang, View ORCID ProfileVladimir Svetlov, Yuri I Wolf, Eugene V Koonin, View ORCID ProfileEvgeny Nudler, View ORCID ProfileIrina Artsimovitch
doi: https://doi.org/10.1101/2021.01.24.428004
Bing Wang
1Department of Microbiology and The Ohio State University, Columbus, OH 43210, USA
2The Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA
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Vladimir Svetlov
3Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA
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  • ORCID record for Vladimir Svetlov
Yuri I Wolf
4National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA
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Eugene V Koonin
4National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA
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Evgeny Nudler
3Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA
5Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA
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Irina Artsimovitch
1Department of Microbiology and The Ohio State University, Columbus, OH 43210, USA
2The Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA
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  • ORCID record for Irina Artsimovitch
  • For correspondence: artsimovitch.1@osu.edu
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Article Information

doi 
https://doi.org/10.1101/2021.01.24.428004
History 
  • April 28, 2021.

Article Versions

  • Version 1 (January 25, 2021 - 13:36).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.

Author Information

  1. Bing Wang1,2,
  2. Vladimir Svetlov3,
  3. Yuri I Wolf4,
  4. Eugene V Koonin4,
  5. Evgeny Nudler3,5 and
  6. Irina Artsimovitch1,2,*
  1. 1Department of Microbiology and The Ohio State University, Columbus, OH 43210, USA
  2. 2The Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA
  3. 3Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA
  4. 4National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA
  5. 5Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA
  1. ↵* Corresponding author; email: artsimovitch.1{at}osu.edu
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Posted April 28, 2021.
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Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides
Bing Wang, Vladimir Svetlov, Yuri I Wolf, Eugene V Koonin, Evgeny Nudler, Irina Artsimovitch
bioRxiv 2021.01.24.428004; doi: https://doi.org/10.1101/2021.01.24.428004
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Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides
Bing Wang, Vladimir Svetlov, Yuri I Wolf, Eugene V Koonin, Evgeny Nudler, Irina Artsimovitch
bioRxiv 2021.01.24.428004; doi: https://doi.org/10.1101/2021.01.24.428004

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