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Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides

Bing Wang, View ORCID ProfileVladimir Svetlov, Yuri I Wolf, Eugene V Koonin, View ORCID ProfileEvgeny Nudler, View ORCID ProfileIrina Artsimovitch
doi: https://doi.org/10.1101/2021.01.24.428004
Bing Wang
1Department of Microbiology and The Ohio State University, Columbus, OH 43210, USA
2The Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA
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Vladimir Svetlov
3Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA
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  • ORCID record for Vladimir Svetlov
Yuri I Wolf
4National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA
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Eugene V Koonin
4National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA
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Evgeny Nudler
3Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA
5Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA
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Irina Artsimovitch
1Department of Microbiology and The Ohio State University, Columbus, OH 43210, USA
2The Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA
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  • ORCID record for Irina Artsimovitch
  • For correspondence: artsimovitch.1@osu.edu
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Posted April 28, 2021.
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Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides
Bing Wang, Vladimir Svetlov, Yuri I Wolf, Eugene V Koonin, Evgeny Nudler, Irina Artsimovitch
bioRxiv 2021.01.24.428004; doi: https://doi.org/10.1101/2021.01.24.428004
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Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides
Bing Wang, Vladimir Svetlov, Yuri I Wolf, Eugene V Koonin, Evgeny Nudler, Irina Artsimovitch
bioRxiv 2021.01.24.428004; doi: https://doi.org/10.1101/2021.01.24.428004

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