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Excitable axonal domains adapt to sensory deprivation in the olfactory system

View ORCID ProfileNicholas M George, View ORCID ProfileWendy B Macklin, View ORCID ProfileDiego Restrepo
doi: https://doi.org/10.1101/2021.01.25.428132
Nicholas M George
1Neuroscience Program, Aurora, United States
2Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States
3Rocky Mountain Taste and Smell Center
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  • ORCID record for Nicholas M George
Wendy B Macklin
2Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States
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  • For correspondence: Diego.restrepo@cuanschutz.edu Wendy.macklin@cuanschutz.edu
Diego Restrepo
2Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States
3Rocky Mountain Taste and Smell Center
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  • For correspondence: Diego.restrepo@cuanschutz.edu Wendy.macklin@cuanschutz.edu
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Abstract

The axon initial segment, nodes of Ranvier, and the oligodendrocyte-derived myelin sheath have significant influence on the firing patterns of neurons and the faithful, coordinated transmission of action potentials to downstream brain regions. In the olfactory bulb, olfactory discrimination tasks lead to adaptive changes in cell firing patterns, and the output signals must reliably travel large distances to other brain regions along highly myelinated tracts. Whether myelinated axons adapt to facilitate olfactory sensory processing is unknown. Here, we investigate the morphology and physiology of mitral cell axons in the adult olfactory system, and show that unilateral sensory deprivation causes system-wide adaptations in axons. Mitral cell spiking patterns and action potentials also adapted to sensory deprivation. Strikingly, both axonal morphology and mitral cell physiology were altered on both the deprived and non-deprived sides, indicating system level adaptations to reduced sensory input. Our work demonstrates a previously unstudied mechanism of plasticity in the olfactory system.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 25, 2021.
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Excitable axonal domains adapt to sensory deprivation in the olfactory system
Nicholas M George, Wendy B Macklin, Diego Restrepo
bioRxiv 2021.01.25.428132; doi: https://doi.org/10.1101/2021.01.25.428132
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Excitable axonal domains adapt to sensory deprivation in the olfactory system
Nicholas M George, Wendy B Macklin, Diego Restrepo
bioRxiv 2021.01.25.428132; doi: https://doi.org/10.1101/2021.01.25.428132

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