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Neutralization of UK-variant VUI-202012/01 with COVAXIN vaccinated human serum

Gajanan N. Sapkal, Pragya D. Yadav, Raches Ella, Gururaj R. Deshpande, Rima R. Sahay, Nivedita Gupta, V Krishna Mohan, Priya Abraham, Samiran Panda, Balram Bhargava
doi: https://doi.org/10.1101/2021.01.26.426986
Gajanan N. Sapkal
1Indian Council of Medical Research-National Institute of Virology, Pune, Maharashtra, India Pin-411021
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Pragya D. Yadav
1Indian Council of Medical Research-National Institute of Virology, Pune, Maharashtra, India Pin-411021
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  • For correspondence: hellopragya22@gmail.com
Raches Ella
2Bharat Biotech International Limited, Genome Valley, Hyderabad, Telangana, India Pin-500078
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Gururaj R. Deshpande
1Indian Council of Medical Research-National Institute of Virology, Pune, Maharashtra, India Pin-411021
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Rima R. Sahay
1Indian Council of Medical Research-National Institute of Virology, Pune, Maharashtra, India Pin-411021
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Nivedita Gupta
3Indian Council of Medical Research, V Ramalingaswami Bhawan, P.O. Box No. 4911, Ansari Nagar, New Delhi, India Pin-110029
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V Krishna Mohan
2Bharat Biotech International Limited, Genome Valley, Hyderabad, Telangana, India Pin-500078
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Priya Abraham
1Indian Council of Medical Research-National Institute of Virology, Pune, Maharashtra, India Pin-411021
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Samiran Panda
3Indian Council of Medical Research, V Ramalingaswami Bhawan, P.O. Box No. 4911, Ansari Nagar, New Delhi, India Pin-110029
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Balram Bhargava
3Indian Council of Medical Research, V Ramalingaswami Bhawan, P.O. Box No. 4911, Ansari Nagar, New Delhi, India Pin-110029
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Abstract

We performed the plaque reduction neutralization test (PRNT50) using sera collected from the recipients of BBV152/COVAXIN™ against hCoV-19/India/20203522 (UK-variant) and hCoV27 19/India/2020Q111 (heterologous strain). A comparable neutralization activity of the vaccinated individuals sera showed against UK-variant and the heterologous strain with similar efficiency, dispel the uncertainty of possible neutralization escape.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • There has been minor revision in the main text.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted January 27, 2021.
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Neutralization of UK-variant VUI-202012/01 with COVAXIN vaccinated human serum
Gajanan N. Sapkal, Pragya D. Yadav, Raches Ella, Gururaj R. Deshpande, Rima R. Sahay, Nivedita Gupta, V Krishna Mohan, Priya Abraham, Samiran Panda, Balram Bhargava
bioRxiv 2021.01.26.426986; doi: https://doi.org/10.1101/2021.01.26.426986
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Neutralization of UK-variant VUI-202012/01 with COVAXIN vaccinated human serum
Gajanan N. Sapkal, Pragya D. Yadav, Raches Ella, Gururaj R. Deshpande, Rima R. Sahay, Nivedita Gupta, V Krishna Mohan, Priya Abraham, Samiran Panda, Balram Bhargava
bioRxiv 2021.01.26.426986; doi: https://doi.org/10.1101/2021.01.26.426986

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