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Somatic mutations reveal widespread mosaicism and mutagenesis in human placentas
View ORCID ProfileTim H. H. Coorens, Thomas R. W. Oliver, Rashesh Sanghvi, Ulla Sovio, Emma Cook, Roser Vento-Tormo, Muzlifah Haniffa, Matthew D. Young, Raheleh Rahbari, Neil Sebire, Peter J. Campbell, View ORCID ProfileD. Stephen Charnock-Jones, Gordon C. S. Smith, Sam Behjati
doi: https://doi.org/10.1101/2021.01.26.428217
Tim H. H. Coorens
1Wellcome Sanger Institute, Hinxton, CB10 1SA, UK
Thomas R. W. Oliver
1Wellcome Sanger Institute, Hinxton, CB10 1SA, UK
2Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK
Rashesh Sanghvi
1Wellcome Sanger Institute, Hinxton, CB10 1SA, UK
Ulla Sovio
3Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, CB2 0SW, UK
Emma Cook
3Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, CB2 0SW, UK
Roser Vento-Tormo
1Wellcome Sanger Institute, Hinxton, CB10 1SA, UK
Muzlifah Haniffa
1Wellcome Sanger Institute, Hinxton, CB10 1SA, UK
4Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
5Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, NE1 4LP, UK
Matthew D. Young
1Wellcome Sanger Institute, Hinxton, CB10 1SA, UK
Raheleh Rahbari
1Wellcome Sanger Institute, Hinxton, CB10 1SA, UK
Neil Sebire
6Great Ormond Street Hospital for Children NHS Foundation Trust, NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK
7UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK
Peter J. Campbell
1Wellcome Sanger Institute, Hinxton, CB10 1SA, UK
D. Stephen Charnock-Jones
3Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, CB2 0SW, UK
8Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EL, UK
Gordon C. S. Smith
3Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, CB2 0SW, UK
8Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EL, UK
Sam Behjati
1Wellcome Sanger Institute, Hinxton, CB10 1SA, UK
2Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK
9Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK
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Posted January 27, 2021.
Somatic mutations reveal widespread mosaicism and mutagenesis in human placentas
Tim H. H. Coorens, Thomas R. W. Oliver, Rashesh Sanghvi, Ulla Sovio, Emma Cook, Roser Vento-Tormo, Muzlifah Haniffa, Matthew D. Young, Raheleh Rahbari, Neil Sebire, Peter J. Campbell, D. Stephen Charnock-Jones, Gordon C. S. Smith, Sam Behjati
bioRxiv 2021.01.26.428217; doi: https://doi.org/10.1101/2021.01.26.428217
Somatic mutations reveal widespread mosaicism and mutagenesis in human placentas
Tim H. H. Coorens, Thomas R. W. Oliver, Rashesh Sanghvi, Ulla Sovio, Emma Cook, Roser Vento-Tormo, Muzlifah Haniffa, Matthew D. Young, Raheleh Rahbari, Neil Sebire, Peter J. Campbell, D. Stephen Charnock-Jones, Gordon C. S. Smith, Sam Behjati
bioRxiv 2021.01.26.428217; doi: https://doi.org/10.1101/2021.01.26.428217
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