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Normalization benchmark of ATAC-seq datasets shows the importance of accounting for GC-content effects

View ORCID ProfileKoen Van den Berge, Hsin-Jung Chou, View ORCID ProfileHector Roux de Bézieux, View ORCID ProfileKelly Street, View ORCID ProfileDavide Risso, View ORCID ProfileJohn Ngai, View ORCID ProfileSandrine Dudoit
doi: https://doi.org/10.1101/2021.01.26.428252
Koen Van den Berge
1Department of Statistics, University of California, Berkeley, CA, USA
2Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium
3Bioinformatics Institute Ghent, Ghent University, Ghent, Belgium
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  • ORCID record for Koen Van den Berge
Hsin-Jung Chou
4Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
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Hector Roux de Bézieux
5Division of Biostatistics, School of Public Health, University of California, Berkeley, CA, USA
6Center for Computational Biology, University of California, Berkeley, CA, USA
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Kelly Street
7Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA
8Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA
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Davide Risso
9Department of Statistical Sciences, University of Padova, Italy
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John Ngai
4Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
10Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
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Sandrine Dudoit
1Department of Statistics, University of California, Berkeley, CA, USA
5Division of Biostatistics, School of Public Health, University of California, Berkeley, CA, USA
6Center for Computational Biology, University of California, Berkeley, CA, USA
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  • ORCID record for Sandrine Dudoit
  • For correspondence: sandrine@stat.berkeley.edu
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Article Information

doi 
https://doi.org/10.1101/2021.01.26.428252
History 
  • May 20, 2021.

Article Versions

  • Version 1 (January 27, 2021 - 03:01).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.

Author Information

  1. Koen Van den Berge1,2,3,
  2. Hsin-Jung Chou4,+,
  3. Hector Roux de Bézieux5,6,
  4. Kelly Street7,8,
  5. Davide Risso9,
  6. John Ngai4,10,† and
  7. Sandrine Dudoit1,5,6,*
  1. 1Department of Statistics, University of California, Berkeley, CA, USA
  2. 2Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium
  3. 3Bioinformatics Institute Ghent, Ghent University, Ghent, Belgium
  4. 4Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
  5. 5Division of Biostatistics, School of Public Health, University of California, Berkeley, CA, USA
  6. 6Center for Computational Biology, University of California, Berkeley, CA, USA
  7. 7Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA
  8. 8Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA
  9. 9Department of Statistical Sciences, University of Padova, Italy
  10. 10Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
  1. ↵*To whom correspondence should be addressed: sandrine{at}stat.berkeley.edu
  • ↵+ Audentes Therapeutics Inc, San Francisco, CA, USA

  • ↵† National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA

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Posted May 20, 2021.
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Normalization benchmark of ATAC-seq datasets shows the importance of accounting for GC-content effects
Koen Van den Berge, Hsin-Jung Chou, Hector Roux de Bézieux, Kelly Street, Davide Risso, John Ngai, Sandrine Dudoit
bioRxiv 2021.01.26.428252; doi: https://doi.org/10.1101/2021.01.26.428252
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Normalization benchmark of ATAC-seq datasets shows the importance of accounting for GC-content effects
Koen Van den Berge, Hsin-Jung Chou, Hector Roux de Bézieux, Kelly Street, Davide Risso, John Ngai, Sandrine Dudoit
bioRxiv 2021.01.26.428252; doi: https://doi.org/10.1101/2021.01.26.428252

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