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E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil

View ORCID ProfilePatrícia Aline Gröhs Ferrareze, View ORCID ProfileVinícius Bonetti Franceschi, View ORCID ProfileAmanda de Menezes Mayer, View ORCID ProfileGabriel Dickin Caldana, Ricardo Ariel Zimerman, View ORCID ProfileClaudia Elizabeth Thompson
doi: https://doi.org/10.1101/2021.01.27.426895
Patrícia Aline Gröhs Ferrareze
1Graduate Program in Health Sciences, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil
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  • ORCID record for Patrícia Aline Gröhs Ferrareze
Vinícius Bonetti Franceschi
2Center of Biotechnology, Graduate Program in Cell and Molecular Biology (PPGBCM), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil
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Amanda de Menezes Mayer
2Center of Biotechnology, Graduate Program in Cell and Molecular Biology (PPGBCM), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil
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Gabriel Dickin Caldana
1Graduate Program in Health Sciences, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil
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Ricardo Ariel Zimerman
3Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brazil
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Claudia Elizabeth Thompson
1Graduate Program in Health Sciences, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil
2Center of Biotechnology, Graduate Program in Cell and Molecular Biology (PPGBCM), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil
4Department of Pharmacosciences, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil
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  • ORCID record for Claudia Elizabeth Thompson
  • For correspondence: cthompson@ufcspa.edu.br thompson.ufcspa@gmail.com
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Abstract

The COVID-19 pandemic caused by SARS-CoV-2 has affected millions of people since its beginning in 2019. The propagation of new lineages and the discovery of key mechanisms adopted by the virus to overlap the immune system are central topics for the entire public health policies, research and disease management. Since the second semester 2020, the mutation E484K has been progressively found in the Brazilian territory, composing different lineages over time. It brought multiple concerns related to the risk of reinfection and the effectiveness of new preventive and treatment strategies due to the possibility of escaping from neutralizing antibodies. To better characterize the current scenario we performed genomic and phylogenetic analyses of the E484K mutated genomes sequenced from Brazilian samples in 2020. From October, 2020, 43.9% of the sequenced genomes present the E484K mutation, which was identified in three different lineages (P1, P2 and B.1.1.33) in four Brazilian regions. We also evaluated the presence of E484K associated mutations and identified selective pressures acting on the spike protein, leading us to some insights about adaptive and purifying selection driving the virus evolution.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted January 27, 2021.
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E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil
Patrícia Aline Gröhs Ferrareze, Vinícius Bonetti Franceschi, Amanda de Menezes Mayer, Gabriel Dickin Caldana, Ricardo Ariel Zimerman, Claudia Elizabeth Thompson
bioRxiv 2021.01.27.426895; doi: https://doi.org/10.1101/2021.01.27.426895
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E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil
Patrícia Aline Gröhs Ferrareze, Vinícius Bonetti Franceschi, Amanda de Menezes Mayer, Gabriel Dickin Caldana, Ricardo Ariel Zimerman, Claudia Elizabeth Thompson
bioRxiv 2021.01.27.426895; doi: https://doi.org/10.1101/2021.01.27.426895

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