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Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K, and N501Y variants by BNT162b2 vaccine-elicited sera

Xuping Xie, Yang Liu, Jianying Liu, Xianwen Zhang, Jing Zou, Camila R. Fontes-Garfias, Hongjie Xia, Kena A. Swanson, Mark Cutler, David Cooper, Vineet D. Menachery, Scott Weaver, Philip R. Dormitzer, Pei-Yong Shi
doi: https://doi.org/10.1101/2021.01.27.427998
Xuping Xie
1Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A.
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Yang Liu
1Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A.
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Jianying Liu
2Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, U.S.A.
3Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, U.S.A.
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Xianwen Zhang
1Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A.
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Jing Zou
1Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A.
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Camila R. Fontes-Garfias
1Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A.
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Hongjie Xia
1Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A.
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Kena A. Swanson
4Pfizer, 401 N Middletown Rd., Pearl River, NY 10960, U.S.A.
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Mark Cutler
4Pfizer, 401 N Middletown Rd., Pearl River, NY 10960, U.S.A.
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David Cooper
4Pfizer, 401 N Middletown Rd., Pearl River, NY 10960, U.S.A.
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Vineet D. Menachery
2Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, U.S.A.
3Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, U.S.A.
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Scott Weaver
2Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, U.S.A.
3Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, U.S.A.
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Philip R. Dormitzer
4Pfizer, 401 N Middletown Rd., Pearl River, NY 10960, U.S.A.
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  • For correspondence: Philip.Dormitzer@pfizer.com peshi@UTMB.edu
Pei-Yong Shi
1Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A.
3Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, U.S.A.
5Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX, U.S.A.
6Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, U.S.A.
7Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, U.S.A.
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  • For correspondence: Philip.Dormitzer@pfizer.com peshi@UTMB.edu
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Article Information

doi 
https://doi.org/10.1101/2021.01.27.427998
History 
  • January 27, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Xuping Xie1,*,
  2. Yang Liu1,*,
  3. Jianying Liu2,3,*,
  4. Xianwen Zhang1,
  5. Jing Zou1,
  6. Camila R. Fontes-Garfias1,
  7. Hongjie Xia1,
  8. Kena A. Swanson4,
  9. Mark Cutler4,
  10. David Cooper4,
  11. Vineet D. Menachery2,3,
  12. Scott Weaver2,3,
  13. Philip R. Dormitzer4,# and
  14. Pei-Yong Shi1,3,5,6,7,#
  1. 1Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A.
  2. 2Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, U.S.A.
  3. 3Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, U.S.A.
  4. 4Pfizer, 401 N Middletown Rd., Pearl River, NY 10960, U.S.A.
  5. 5Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX, U.S.A.
  6. 6Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, U.S.A.
  7. 7Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, U.S.A.
  1. ↵#Correspondence: P.R.D. (Philip.Dormitzer{at}pfizer.com) or P.-Y.S. (peshi{at}UTMB.edu)
  1. ↵* X.X., Y.L., and J.L. contributed equally to this study.

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Posted January 27, 2021.
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Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K, and N501Y variants by BNT162b2 vaccine-elicited sera
Xuping Xie, Yang Liu, Jianying Liu, Xianwen Zhang, Jing Zou, Camila R. Fontes-Garfias, Hongjie Xia, Kena A. Swanson, Mark Cutler, David Cooper, Vineet D. Menachery, Scott Weaver, Philip R. Dormitzer, Pei-Yong Shi
bioRxiv 2021.01.27.427998; doi: https://doi.org/10.1101/2021.01.27.427998
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Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K, and N501Y variants by BNT162b2 vaccine-elicited sera
Xuping Xie, Yang Liu, Jianying Liu, Xianwen Zhang, Jing Zou, Camila R. Fontes-Garfias, Hongjie Xia, Kena A. Swanson, Mark Cutler, David Cooper, Vineet D. Menachery, Scott Weaver, Philip R. Dormitzer, Pei-Yong Shi
bioRxiv 2021.01.27.427998; doi: https://doi.org/10.1101/2021.01.27.427998

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