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Multiomics single-cell analysis of human pancreatic islets reveals novel cellular states in health and type 1 diabetes
Maria Fasolino, Gregory W. Schwartz, Maria L. Golson, Yue J. Wang, Ashleigh Morgan, Chengyang Liu, Jonathan Schug, Jinping Liu, Minghui Wu, Daniel Traum, Ayano Kondo, Catherine L. May, Naomi Goldman, Wenliang Wang, the HPAP Consortium, Michael Feldman, Jason H. Moore, Alberto S. Japp, Michael R. Betts, Robert B. Faryabi, Ali Naji, Klaus H. Kaestner, Golnaz Vahedi
doi: https://doi.org/10.1101/2021.01.28.428598
Maria Fasolino
1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
2Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
3Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
4Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
Gregory W. Schwartz
2Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
3Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
5Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
6Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
8Institute for Biomedical Informatics
Maria L. Golson
1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
4Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
Yue J. Wang
1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
4Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
Ashleigh Morgan
1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
4Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
Chengyang Liu
4Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
9Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
Jonathan Schug
1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
Jinping Liu
1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
4Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
Minghui Wu
1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
4Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
Daniel Traum
1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
4Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
Ayano Kondo
1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
4Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
Catherine L. May
1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
4Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
Naomi Goldman
1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
2Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
3Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
4Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
Wenliang Wang
1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
2Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
3Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
4Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
7The Human Pancreas Analysis Program
Michael Feldman
5Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
8Institute for Biomedical Informatics
Jason H. Moore
1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
8Institute for Biomedical Informatics
Alberto S. Japp
7The Human Pancreas Analysis Program
10Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
Michael R. Betts
7The Human Pancreas Analysis Program
10Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
Robert B. Faryabi
2Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
3Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
5Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
6Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
8Institute for Biomedical Informatics
Ali Naji
2Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
4Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
9Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
Klaus H. Kaestner
1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
3Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
4Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
Golnaz Vahedi
1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
2Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
3Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
4Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
6Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
7The Human Pancreas Analysis Program
8Institute for Biomedical Informatics
Article usage
Posted January 31, 2021.
Multiomics single-cell analysis of human pancreatic islets reveals novel cellular states in health and type 1 diabetes
Maria Fasolino, Gregory W. Schwartz, Maria L. Golson, Yue J. Wang, Ashleigh Morgan, Chengyang Liu, Jonathan Schug, Jinping Liu, Minghui Wu, Daniel Traum, Ayano Kondo, Catherine L. May, Naomi Goldman, Wenliang Wang, the HPAP Consortium, Michael Feldman, Jason H. Moore, Alberto S. Japp, Michael R. Betts, Robert B. Faryabi, Ali Naji, Klaus H. Kaestner, Golnaz Vahedi
bioRxiv 2021.01.28.428598; doi: https://doi.org/10.1101/2021.01.28.428598
Multiomics single-cell analysis of human pancreatic islets reveals novel cellular states in health and type 1 diabetes
Maria Fasolino, Gregory W. Schwartz, Maria L. Golson, Yue J. Wang, Ashleigh Morgan, Chengyang Liu, Jonathan Schug, Jinping Liu, Minghui Wu, Daniel Traum, Ayano Kondo, Catherine L. May, Naomi Goldman, Wenliang Wang, the HPAP Consortium, Michael Feldman, Jason H. Moore, Alberto S. Japp, Michael R. Betts, Robert B. Faryabi, Ali Naji, Klaus H. Kaestner, Golnaz Vahedi
bioRxiv 2021.01.28.428598; doi: https://doi.org/10.1101/2021.01.28.428598
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