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Angular and Linear Speed Cells in the Parahippocampal Circuits

View ORCID ProfileDavide Spalla, View ORCID ProfileAlessandro Treves, Charlotte N. Boccara
doi: https://doi.org/10.1101/2021.01.28.428631
Davide Spalla
1Sissa, Via Bonomea 265, 34136 Trieste, Italy
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Alessandro Treves
1Sissa, Via Bonomea 265, 34136 Trieste, Italy
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Charlotte N. Boccara
2University of Oslo, Sognsvannsveien 9 Domus Medica, 0372 Oslo, Norway
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  • For correspondence: charlotte.boccara@medisin.uio.no
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Abstract

An essential role of the hippocampal region is to integrate information to compute and update representations. How this transpires is highly debated. Many theories hinge on the integration of self-motion signals and the existence of continuous attractor networks (CAN). CAN models hypothesise that neurons coding for navigational correlates – such as position and direction – receive inputs from cells conjunctively coding for position, direction and self-motion. As yet, such conjunctive coding had not been found in the hippocampal region. Here, we report neurons coding for angular and linear velocity, distributed across the medial entorhinal cortex, the presubiculum and the parasubiculum. These self-motion neurons often conjunctively encoded position and/or direction, yet lacked a structured organisation, calling for the revision of current CAN models. These results offer insights as to how linear/angular speed – derivative in time of position/direction – may allow the updating of spatial representations, possibly uncovering a generalised algorithm to update any representation.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 29, 2021.
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Angular and Linear Speed Cells in the Parahippocampal Circuits
Davide Spalla, Alessandro Treves, Charlotte N. Boccara
bioRxiv 2021.01.28.428631; doi: https://doi.org/10.1101/2021.01.28.428631
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Angular and Linear Speed Cells in the Parahippocampal Circuits
Davide Spalla, Alessandro Treves, Charlotte N. Boccara
bioRxiv 2021.01.28.428631; doi: https://doi.org/10.1101/2021.01.28.428631

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