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Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer
Karin Pelka, Matan Hofree, Jonathan Chen, Siranush Sarkizova, Joshua D. Pirl, Vjola Jorgji, Alborz Bejnood, Danielle Dionne, William H. Ge, Katherine H. Xu, Sherry X. Chao, Daniel R. Zollinger, David J. Lieb, Jason W. Reeves, Christopher A. Fuhrman, Margaret L. Hoang, Toni Delorey, Lan T. Nguyen, Julia Waldman, Max Klapholz, Isaac Wakiro, Ofir Cohen, Christopher S. Smillie, Michael S. Cuoco, Jingyi Wu, Mei-ju Su, Jason Yeung, Brinda Vijaykumar, Angela M. Magnuson, Natasha Asinovski, Tabea Moll, Max N. Goder-Reiser, Anise S. Applebaum, Lauren K. Brais, Laura K. DelloStritto, Sarah L. Denning, Susannah T. Phillips, Emma K. Hill, Julia K. Meehan, Dennie T. Frederick, Tatyana Sharova, Abhay Kanodia, Ellen Z. Todres, Judit Jané-Valbuena, Moshe Biton, Benjamin Izar, Conner D. Lambden, Thomas E. Clancy, Ronald Bleday, Nelya Melnitchouk, Jennifer Irani, Hiroko Kunitake, David L. Berger, Amitabh Srivastava, Jason L. Hornick, Shuji Ogino, Asaf Rotem, Sébastien Vigneau, Bruce E. Johnson, Ryan Corcoran, Arlene H. Sharpe, Vijay K. Kuchroo, Kimmie Ng, Marios Giannakis, Linda T. Nieman, Genevieve M. Boland, Andrew J. Aguirre, Ana C. Anderson, Orit Rozenblatt-Rosen, Aviv Regev, Nir Hacohen
doi: https://doi.org/10.1101/2021.01.30.426796
Karin Pelka
1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA
2Massachusetts General Hospital Cancer Center, Harvard Medical School (HMS), Boston, MA, USA
Matan Hofree
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Jonathan Chen
1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA
2Massachusetts General Hospital Cancer Center, Harvard Medical School (HMS), Boston, MA, USA
4Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
Siranush Sarkizova
1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA
Joshua D. Pirl
1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA
Vjola Jorgji
2Massachusetts General Hospital Cancer Center, Harvard Medical School (HMS), Boston, MA, USA
4Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
Alborz Bejnood
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Danielle Dionne
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
William H. Ge
1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA
Katherine H. Xu
2Massachusetts General Hospital Cancer Center, Harvard Medical School (HMS), Boston, MA, USA
Sherry X. Chao
1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA
5Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
Daniel R. Zollinger
6NanoString Technologies Inc., Seattle, WA, USA
David J. Lieb
1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA
Jason W. Reeves
6NanoString Technologies Inc., Seattle, WA, USA
Christopher A. Fuhrman
6NanoString Technologies Inc., Seattle, WA, USA
Margaret L. Hoang
6NanoString Technologies Inc., Seattle, WA, USA
Toni Delorey
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Lan T. Nguyen
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Julia Waldman
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Max Klapholz
7Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA
Isaac Wakiro
8Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Ofir Cohen
1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA
8Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
9Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Christopher S. Smillie
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Michael S. Cuoco
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Jingyi Wu
8Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Mei-ju Su
8Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Jason Yeung
8Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Brinda Vijaykumar
10Department of Immunology, Harvard Medical School, Boston, MA, USA
Angela M. Magnuson
10Department of Immunology, Harvard Medical School, Boston, MA, USA
Natasha Asinovski
10Department of Immunology, Harvard Medical School, Boston, MA, USA
Tabea Moll
11Clinical Research Center, Massachusetts General Hospital, Boston, MA, USA
Max N. Goder-Reiser
11Clinical Research Center, Massachusetts General Hospital, Boston, MA, USA
Anise S. Applebaum
11Clinical Research Center, Massachusetts General Hospital, Boston, MA, USA
Lauren K. Brais
12Clinical Research Center, Dana-Farber Cancer Institute, Boston, MA, USA
Laura K. DelloStritto
8Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Sarah L. Denning
12Clinical Research Center, Dana-Farber Cancer Institute, Boston, MA, USA
Susannah T. Phillips
11Clinical Research Center, Massachusetts General Hospital, Boston, MA, USA
Emma K. Hill
12Clinical Research Center, Dana-Farber Cancer Institute, Boston, MA, USA
Julia K. Meehan
12Clinical Research Center, Dana-Farber Cancer Institute, Boston, MA, USA
Dennie T. Frederick
11Clinical Research Center, Massachusetts General Hospital, Boston, MA, USA
Tatyana Sharova
11Clinical Research Center, Massachusetts General Hospital, Boston, MA, USA
Abhay Kanodia
8Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Ellen Z. Todres
1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA
Judit Jané-Valbuena
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Moshe Biton
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
13Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA
Benjamin Izar
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
8Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
9Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
14Columbia Center for Translational Immunology, New York, NY; Columbia University Medical Center, Division of Hematology and Oncology, New York, NY; Program for Mathematical Genomics, Columbia University, New York, NY
Conner D. Lambden
7Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA
Thomas E. Clancy
15Department of Surgery, Brigham and Women’s Hospital, Boston, MA, USA
Ronald Bleday
15Department of Surgery, Brigham and Women’s Hospital, Boston, MA, USA
Nelya Melnitchouk
15Department of Surgery, Brigham and Women’s Hospital, Boston, MA, USA
Jennifer Irani
15Department of Surgery, Brigham and Women’s Hospital, Boston, MA, USA
Hiroko Kunitake
16Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
David L. Berger
16Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
Amitabh Srivastava
17Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA
Jason L. Hornick
17Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA
Shuji Ogino
1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA
17Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA
Asaf Rotem
8Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Sébastien Vigneau
8Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Bruce E. Johnson
8Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
9Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Ryan Corcoran
2Massachusetts General Hospital Cancer Center, Harvard Medical School (HMS), Boston, MA, USA
19Department of Medicine, Harvard Medical School, Boston, MA, USA
Arlene H. Sharpe
7Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA
18Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
Vijay K. Kuchroo
7Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA
Kimmie Ng
9Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Marios Giannakis
1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA
9Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Linda T. Nieman
2Massachusetts General Hospital Cancer Center, Harvard Medical School (HMS), Boston, MA, USA
Genevieve M. Boland
2Massachusetts General Hospital Cancer Center, Harvard Medical School (HMS), Boston, MA, USA
16Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
Andrew J. Aguirre
1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA
9Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Ana C. Anderson
7Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA
Orit Rozenblatt-Rosen
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Aviv Regev
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
20Howard Hughes Medical Institute and Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
Nir Hacohen
1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA
2Massachusetts General Hospital Cancer Center, Harvard Medical School (HMS), Boston, MA, USA
10Department of Immunology, Harvard Medical School, Boston, MA, USA
Article usage
Posted February 02, 2021.
Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer
Karin Pelka, Matan Hofree, Jonathan Chen, Siranush Sarkizova, Joshua D. Pirl, Vjola Jorgji, Alborz Bejnood, Danielle Dionne, William H. Ge, Katherine H. Xu, Sherry X. Chao, Daniel R. Zollinger, David J. Lieb, Jason W. Reeves, Christopher A. Fuhrman, Margaret L. Hoang, Toni Delorey, Lan T. Nguyen, Julia Waldman, Max Klapholz, Isaac Wakiro, Ofir Cohen, Christopher S. Smillie, Michael S. Cuoco, Jingyi Wu, Mei-ju Su, Jason Yeung, Brinda Vijaykumar, Angela M. Magnuson, Natasha Asinovski, Tabea Moll, Max N. Goder-Reiser, Anise S. Applebaum, Lauren K. Brais, Laura K. DelloStritto, Sarah L. Denning, Susannah T. Phillips, Emma K. Hill, Julia K. Meehan, Dennie T. Frederick, Tatyana Sharova, Abhay Kanodia, Ellen Z. Todres, Judit Jané-Valbuena, Moshe Biton, Benjamin Izar, Conner D. Lambden, Thomas E. Clancy, Ronald Bleday, Nelya Melnitchouk, Jennifer Irani, Hiroko Kunitake, David L. Berger, Amitabh Srivastava, Jason L. Hornick, Shuji Ogino, Asaf Rotem, Sébastien Vigneau, Bruce E. Johnson, Ryan Corcoran, Arlene H. Sharpe, Vijay K. Kuchroo, Kimmie Ng, Marios Giannakis, Linda T. Nieman, Genevieve M. Boland, Andrew J. Aguirre, Ana C. Anderson, Orit Rozenblatt-Rosen, Aviv Regev, Nir Hacohen
bioRxiv 2021.01.30.426796; doi: https://doi.org/10.1101/2021.01.30.426796
Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer
Karin Pelka, Matan Hofree, Jonathan Chen, Siranush Sarkizova, Joshua D. Pirl, Vjola Jorgji, Alborz Bejnood, Danielle Dionne, William H. Ge, Katherine H. Xu, Sherry X. Chao, Daniel R. Zollinger, David J. Lieb, Jason W. Reeves, Christopher A. Fuhrman, Margaret L. Hoang, Toni Delorey, Lan T. Nguyen, Julia Waldman, Max Klapholz, Isaac Wakiro, Ofir Cohen, Christopher S. Smillie, Michael S. Cuoco, Jingyi Wu, Mei-ju Su, Jason Yeung, Brinda Vijaykumar, Angela M. Magnuson, Natasha Asinovski, Tabea Moll, Max N. Goder-Reiser, Anise S. Applebaum, Lauren K. Brais, Laura K. DelloStritto, Sarah L. Denning, Susannah T. Phillips, Emma K. Hill, Julia K. Meehan, Dennie T. Frederick, Tatyana Sharova, Abhay Kanodia, Ellen Z. Todres, Judit Jané-Valbuena, Moshe Biton, Benjamin Izar, Conner D. Lambden, Thomas E. Clancy, Ronald Bleday, Nelya Melnitchouk, Jennifer Irani, Hiroko Kunitake, David L. Berger, Amitabh Srivastava, Jason L. Hornick, Shuji Ogino, Asaf Rotem, Sébastien Vigneau, Bruce E. Johnson, Ryan Corcoran, Arlene H. Sharpe, Vijay K. Kuchroo, Kimmie Ng, Marios Giannakis, Linda T. Nieman, Genevieve M. Boland, Andrew J. Aguirre, Ana C. Anderson, Orit Rozenblatt-Rosen, Aviv Regev, Nir Hacohen
bioRxiv 2021.01.30.426796; doi: https://doi.org/10.1101/2021.01.30.426796
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