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Identification of a conserved neutralizing epitope present on spike proteins from all highly pathogenic coronaviruses

Yimin Huang, View ORCID ProfileAnnalee W. Nguyen, Ching-Lin Hsieh, Rui Silva, Oladimeji S. Olaluwoye, Rebecca E. Wilen, Tamer S. Kaoud, Laura R. Azouz, Ahlam N. Qerqez, Kevin C. Le, Amanda L. Bohanon, Andrea M. DiVenere, Yutong Liu, Alison G. Lee, Dzifa Amengor, Sophie R. Shoemaker, View ORCID ProfileShawn M. Costello, Susan Marqusee, Kevin N. Dalby, View ORCID ProfileSheena D’Arcy, View ORCID ProfileJason S. McLellan, View ORCID ProfileJennifer A. Maynard
doi: https://doi.org/10.1101/2021.01.31.428824
Yimin Huang
1Department of Molecular Biosciences, The University of Texas, Austin, TX 78712, USA
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Annalee W. Nguyen
2Department of Chemical Engineering, The University of Texas, Austin, TX 78712, USA
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  • ORCID record for Annalee W. Nguyen
Ching-Lin Hsieh
1Department of Molecular Biosciences, The University of Texas, Austin, TX 78712, USA
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Rui Silva
1Department of Molecular Biosciences, The University of Texas, Austin, TX 78712, USA
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Oladimeji S. Olaluwoye
4Department of Chemistry and Biochemistry, The University of Texas, Dallas, TX 75080, USA
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Rebecca E. Wilen
2Department of Chemical Engineering, The University of Texas, Austin, TX 78712, USA
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Tamer S. Kaoud
3Division of Chemical Biology and Medicinal Chemistry, The University of Texas, Austin, TX 78712, USA
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Laura R. Azouz
2Department of Chemical Engineering, The University of Texas, Austin, TX 78712, USA
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Ahlam N. Qerqez
2Department of Chemical Engineering, The University of Texas, Austin, TX 78712, USA
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Kevin C. Le
2Department of Chemical Engineering, The University of Texas, Austin, TX 78712, USA
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Amanda L. Bohanon
1Department of Molecular Biosciences, The University of Texas, Austin, TX 78712, USA
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Andrea M. DiVenere
2Department of Chemical Engineering, The University of Texas, Austin, TX 78712, USA
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Yutong Liu
2Department of Chemical Engineering, The University of Texas, Austin, TX 78712, USA
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Alison G. Lee
1Department of Molecular Biosciences, The University of Texas, Austin, TX 78712, USA
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Dzifa Amengor
1Department of Molecular Biosciences, The University of Texas, Austin, TX 78712, USA
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Sophie R. Shoemaker
5Department of Molecular & Cell Biology, University of California, Berkeley, CA 94720, USA
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Shawn M. Costello
6Biophysics Graduate Program, University of California, Berkeley, CA 94720, USA
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  • ORCID record for Shawn M. Costello
Susan Marqusee
5Department of Molecular & Cell Biology, University of California, Berkeley, CA 94720, USA
7Department of Chemistry, University of California, Berkeley, CA 94720, USA
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Kevin N. Dalby
3Division of Chemical Biology and Medicinal Chemistry, The University of Texas, Austin, TX 78712, USA
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Sheena D’Arcy
4Department of Chemistry and Biochemistry, The University of Texas, Dallas, TX 75080, USA
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  • ORCID record for Sheena D’Arcy
Jason S. McLellan
1Department of Molecular Biosciences, The University of Texas, Austin, TX 78712, USA
8LaMontagne Center for Infectious Diseases, The University of Texas, Austin, TX 78712, USA
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  • For correspondence: maynard@che.utexas.edu
Jennifer A. Maynard
2Department of Chemical Engineering, The University of Texas, Austin, TX 78712, USA
8LaMontagne Center for Infectious Diseases, The University of Texas, Austin, TX 78712, USA
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  • ORCID record for Jennifer A. Maynard
  • For correspondence: maynard@che.utexas.edu
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Article Information

doi 
https://doi.org/10.1101/2021.01.31.428824
History 
  • August 20, 2021.

Article Versions

  • Version 1 (February 1, 2021 - 12:51).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.

Author Information

  1. Yimin Huang1,†,
  2. Annalee W. Nguyen2,†,
  3. Ching-Lin Hsieh1,
  4. Rui Silva1,
  5. Oladimeji S. Olaluwoye4,
  6. Rebecca E. Wilen2,
  7. Tamer S. Kaoud3,
  8. Laura R. Azouz2,
  9. Ahlam N. Qerqez2,
  10. Kevin C. Le2,
  11. Amanda L. Bohanon1,
  12. Andrea M. DiVenere2,
  13. Yutong Liu2,
  14. Alison G. Lee1,
  15. Dzifa Amengor1,
  16. Sophie R. Shoemaker5,
  17. Shawn M. Costello6,
  18. Susan Marqusee5,7,
  19. Kevin N. Dalby3,
  20. Sheena D’Arcy4,
  21. Jason S. McLellan1,8,* and
  22. Jennifer A. Maynard2,8,*
  1. 1Department of Molecular Biosciences, The University of Texas, Austin, TX 78712, USA
  2. 2Department of Chemical Engineering, The University of Texas, Austin, TX 78712, USA
  3. 3Division of Chemical Biology and Medicinal Chemistry, The University of Texas, Austin, TX 78712, USA
  4. 4Department of Chemistry and Biochemistry, The University of Texas, Dallas, TX 75080, USA
  5. 5Department of Molecular & Cell Biology, University of California, Berkeley, CA 94720, USA
  6. 6Biophysics Graduate Program, University of California, Berkeley, CA 94720, USA
  7. 7Department of Chemistry, University of California, Berkeley, CA 94720, USA
  8. 8LaMontagne Center for Infectious Diseases, The University of Texas, Austin, TX 78712, USA
  1. ↵*Corresponding author. email: maynard{at}che.utexas.edu
  1. ↵† These authors contributed equally to this work.

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Identification of a conserved neutralizing epitope present on spike proteins from all highly pathogenic coronaviruses
Yimin Huang, Annalee W. Nguyen, Ching-Lin Hsieh, Rui Silva, Oladimeji S. Olaluwoye, Rebecca E. Wilen, Tamer S. Kaoud, Laura R. Azouz, Ahlam N. Qerqez, Kevin C. Le, Amanda L. Bohanon, Andrea M. DiVenere, Yutong Liu, Alison G. Lee, Dzifa Amengor, Sophie R. Shoemaker, Shawn M. Costello, Susan Marqusee, Kevin N. Dalby, Sheena D’Arcy, Jason S. McLellan, Jennifer A. Maynard
bioRxiv 2021.01.31.428824; doi: https://doi.org/10.1101/2021.01.31.428824
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Identification of a conserved neutralizing epitope present on spike proteins from all highly pathogenic coronaviruses
Yimin Huang, Annalee W. Nguyen, Ching-Lin Hsieh, Rui Silva, Oladimeji S. Olaluwoye, Rebecca E. Wilen, Tamer S. Kaoud, Laura R. Azouz, Ahlam N. Qerqez, Kevin C. Le, Amanda L. Bohanon, Andrea M. DiVenere, Yutong Liu, Alison G. Lee, Dzifa Amengor, Sophie R. Shoemaker, Shawn M. Costello, Susan Marqusee, Kevin N. Dalby, Sheena D’Arcy, Jason S. McLellan, Jennifer A. Maynard
bioRxiv 2021.01.31.428824; doi: https://doi.org/10.1101/2021.01.31.428824

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