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Dendritic domain-specific sampling of long-range axons shapes feedforward and feedback connectivity of L5 neurons

View ORCID ProfileAlessandro R. Galloni, Zhiwen Ye, View ORCID ProfileEde Rancz
doi: https://doi.org/10.1101/2021.01.31.429033
Alessandro R. Galloni
1The Francis Crick Institute, London, United Kingdom
2University College London, United Kingdom
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Zhiwen Ye
1The Francis Crick Institute, London, United Kingdom
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Ede Rancz
1The Francis Crick Institute, London, United Kingdom
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  • For correspondence: ede.rancz@crick.ac.uk
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Abstract

Feedforward and feedback pathways interact in specific dendritic domains to enable cognitive functions such as predictive processing and learning. Based on axonal projections, hierarchically lower areas are thought to form synapses primarily on dendrites in middle cortical layers, while higher-order areas are posited to target dendrites in layer 1 and in deep layers. However, the extent to which functional synapses form in regions of axo-dendritic overlap has not been extensively studied. Here, we use viral tracing in the secondary visual cortex of mice to map brain-wide inputs to thick-tufted layer 5 pyramidal neurons. Furthermore, we provide a comprehensive map of input locations through subcellular optogenetic circuit mapping. We show that input pathways target distinct dendritic domains with far greater specificity than appears from their axonal branching, often deviating substantially from the canonical patterns. Common assumptions regarding the dendrite-level interaction of feedforward and feedback inputs may thus need revisiting.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted August 02, 2021.
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Dendritic domain-specific sampling of long-range axons shapes feedforward and feedback connectivity of L5 neurons
Alessandro R. Galloni, Zhiwen Ye, Ede Rancz
bioRxiv 2021.01.31.429033; doi: https://doi.org/10.1101/2021.01.31.429033
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Dendritic domain-specific sampling of long-range axons shapes feedforward and feedback connectivity of L5 neurons
Alessandro R. Galloni, Zhiwen Ye, Ede Rancz
bioRxiv 2021.01.31.429033; doi: https://doi.org/10.1101/2021.01.31.429033

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