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Neutralization of SARS-CoV-2 VOC 501Y.V2 by human antisera elicited by both inactivated BBIBP-CorV and recombinant dimeric RBD ZF2001 vaccines

Baoying Huang, Lianpan Dai, Hui Wang, Zhongyu Hu, Xiaoming Yang, Wenjie Tan, George F. Gao
doi: https://doi.org/10.1101/2021.02.01.429069
Baoying Huang
1NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China
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Lianpan Dai
2CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China
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Hui Wang
3Beijing Institute of Biological Products Company Limited, Beijing, China
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Zhongyu Hu
4National Institute for Food and Drug Control, Beijing, 100050, China
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Xiaoming Yang
3Beijing Institute of Biological Products Company Limited, Beijing, China
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Wenjie Tan
1NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China
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  • For correspondence: gaof@im.ac.cn tanwj@ivdc.chinacdc.cn
George F. Gao
1NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China
2CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China
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  • For correspondence: gaof@im.ac.cn tanwj@ivdc.chinacdc.cn
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Abstract

Recently, the emerged and rapidly spreading SARS-CoV-2 variant of concern (VOC) 501Y.V2 with 10 amino acids in spike protein were found to escape host immunity induced by infection or vaccination. Global concerns have been raised for its potential to affect vaccine efficacy. Here, we evaluated the neutralization activities of two vaccines developed in China against 501Y.V2. One is licensed inactivated vaccine BBIBP-CorV and the other one is recombinant dimeric receptor-binding domain (RBD) vaccine ZF2001. Encouragingly, both vaccines largely preserved neutralizing titres, with slightly reduction, against 501Y.V2 authentic virus compare to their titres against both original SARS-CoV-2 and the currently circulating D614G virus. These data indicated that 501Y.V2 variant will not escape the immunity induced by vaccines targeting whole virus or RBD.

Competing Interest Statement

Lianpan Dai and George F.Gao are listed as inventors on patent applications for RBD-dimer-based coronavirus vaccines.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted February 02, 2021.
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Neutralization of SARS-CoV-2 VOC 501Y.V2 by human antisera elicited by both inactivated BBIBP-CorV and recombinant dimeric RBD ZF2001 vaccines
Baoying Huang, Lianpan Dai, Hui Wang, Zhongyu Hu, Xiaoming Yang, Wenjie Tan, George F. Gao
bioRxiv 2021.02.01.429069; doi: https://doi.org/10.1101/2021.02.01.429069
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Neutralization of SARS-CoV-2 VOC 501Y.V2 by human antisera elicited by both inactivated BBIBP-CorV and recombinant dimeric RBD ZF2001 vaccines
Baoying Huang, Lianpan Dai, Hui Wang, Zhongyu Hu, Xiaoming Yang, Wenjie Tan, George F. Gao
bioRxiv 2021.02.01.429069; doi: https://doi.org/10.1101/2021.02.01.429069

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