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Basal-to-classical phenotypic switch of pancreatic cancer cells upon integration into the duodenal epithelium

Benedek Bozóky, Carlos Fernández Moro, Carina Strell, Ingemar Ernberg, Laszlo Szekely, Marco Gerling, Béla Bozóky
doi: https://doi.org/10.1101/2021.02.01.429212
Benedek Bozóky
1Theme Cancer, oncology, Karolinska University Hospital, 17 176 Solna, Sweden
2Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Solnavägen 9, 171 65 Solna, Sweden
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  • For correspondence: marco.gerling@ki.se benedek.bozoky@ki.se
Carlos Fernández Moro
3Department of Clinical Pathology/Cytology, Karolinska University Hospital, Stockholm, 14186, Sweden
4Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, 14186 Stockholm, Sweden
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Carina Strell
5Department of Oncology-Pathology, Karolinska Institutet, 17164 Solna, Sweden
6Department of Immunology, Genetics and Pathology, Uppsala University, 75185 Uppsala, Sweden
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Ingemar Ernberg
2Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Solnavägen 9, 171 65 Solna, Sweden
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Laszlo Szekely
3Department of Clinical Pathology/Cytology, Karolinska University Hospital, Stockholm, 14186, Sweden
4Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, 14186 Stockholm, Sweden
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Marco Gerling
1Theme Cancer, oncology, Karolinska University Hospital, 17 176 Solna, Sweden
7Department of Biosciences and Nutrition, Karolinska Institutet, 14183 Huddinge, Sweden
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  • For correspondence: marco.gerling@ki.se benedek.bozoky@ki.se
Béla Bozóky
3Department of Clinical Pathology/Cytology, Karolinska University Hospital, Stockholm, 14186, Sweden
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Article Information

doi 
https://doi.org/10.1101/2021.02.01.429212
History 
  • February 2, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Benedek Bozóky1,2,#,
  2. Carlos Fernández Moro3,4,
  3. Carina Strell5,6,
  4. Ingemar Ernberg2,
  5. Laszlo Szekely3,4,
  6. Marco Gerling1,7,#,* and
  7. Béla Bozóky3,*
  1. 1Theme Cancer, oncology, Karolinska University Hospital, 17 176 Solna, Sweden
  2. 2Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Solnavägen 9, 171 65 Solna, Sweden
  3. 3Department of Clinical Pathology/Cytology, Karolinska University Hospital, Stockholm, 14186, Sweden
  4. 4Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, 14186 Stockholm, Sweden
  5. 5Department of Oncology-Pathology, Karolinska Institutet, 17164 Solna, Sweden
  6. 6Department of Immunology, Genetics and Pathology, Uppsala University, 75185 Uppsala, Sweden
  7. 7Department of Biosciences and Nutrition, Karolinska Institutet, 14183 Huddinge, Sweden
  1. ↵#To whom correspondence should be addressed: Dr. med. Marco Gerling,
    Karolinska Institutet, Department of Biosciences and Nutrition Hälsovägen 7, 141 83 Huddinge Sweden, marco.gerling{at}ki.se, Benedek Bozóky Nobels väg 16, Karolinska Institutet, Campus Solna Box 280, 171 77 Stockholm Sweden, benedek.bozoky{at}ki.se
  1. Author contributions: Benedek B, Béla B, MG, CF, and CS generated and analyzed data, LS and IE advised on study design, Béla B conceived the study, Benedek B, CFM and MG wrote the manuscript, CS, IE, and LS commented on the manuscript.

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Posted February 02, 2021.
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Basal-to-classical phenotypic switch of pancreatic cancer cells upon integration into the duodenal epithelium
Benedek Bozóky, Carlos Fernández Moro, Carina Strell, Ingemar Ernberg, Laszlo Szekely, Marco Gerling, Béla Bozóky
bioRxiv 2021.02.01.429212; doi: https://doi.org/10.1101/2021.02.01.429212
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Basal-to-classical phenotypic switch of pancreatic cancer cells upon integration into the duodenal epithelium
Benedek Bozóky, Carlos Fernández Moro, Carina Strell, Ingemar Ernberg, Laszlo Szekely, Marco Gerling, Béla Bozóky
bioRxiv 2021.02.01.429212; doi: https://doi.org/10.1101/2021.02.01.429212

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