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Akr1d1-/- mice have a sexually dimorphic metabolic phenotype with reduced fat mass, increased insulin sensitivity and hypertriglyceridemia in males
View ORCID ProfileLaura L Gathercole, View ORCID ProfileNikolaos Nikolaou, Anastasia Arvaniti, Shelley E Harris, Toryn M Poolman, Jonathan M Hazlehurst, Denise V Kratschmar, Marijana Todorčević, Ahmad Moolla, Niall Dempster, Ryan C Pink, Michael F Saikali, Liz Bentley, Trevor M Penning, Claes Ohlsson, Carolyn L Cummins, Matti Poutanen, Alex Odermatt, Roger D Cox, Jeremy W Tomlinson
doi: https://doi.org/10.1101/2021.02.02.429227
Laura L Gathercole
1Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK, OX3 7LE, UK
2Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, OX3 0BP, UK
Nikolaos Nikolaou
1Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK, OX3 7LE, UK
Anastasia Arvaniti
1Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK, OX3 7LE, UK
2Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, OX3 0BP, UK
Shelley E Harris
1Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK, OX3 7LE, UK
Toryn M Poolman
1Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK, OX3 7LE, UK
Jonathan M Hazlehurst
1Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK, OX3 7LE, UK
3Institute of Metabolism and Systems Research, University of Birmingham, UK, Birmingham, B15 2TT, UK
Denise V Kratschmar
4Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
Marijana Todorčević
1Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK, OX3 7LE, UK
Ahmad Moolla
1Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK, OX3 7LE, UK
Niall Dempster
1Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK, OX3 7LE, UK
Ryan C Pink
2Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, OX3 0BP, UK
Michael F Saikali
5Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada
Liz Bentley
6Mammalian Genetics Unit, Medical Research Council Harwell, Oxford, OX11 0RD, UK
Trevor M Penning
7Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-6160, US
Claes Ohlsson
8Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Carolyn L Cummins
5Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada
Matti Poutanen
8Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
9Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Kiinamyllynkatu 10, FI-20520 Turku, Finland
Alex Odermatt
4Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
Roger D Cox
6Mammalian Genetics Unit, Medical Research Council Harwell, Oxford, OX11 0RD, UK
Jeremy W Tomlinson
1Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK, OX3 7LE, UK
Posted February 02, 2021.
Akr1d1-/- mice have a sexually dimorphic metabolic phenotype with reduced fat mass, increased insulin sensitivity and hypertriglyceridemia in males
Laura L Gathercole, Nikolaos Nikolaou, Anastasia Arvaniti, Shelley E Harris, Toryn M Poolman, Jonathan M Hazlehurst, Denise V Kratschmar, Marijana Todorčević, Ahmad Moolla, Niall Dempster, Ryan C Pink, Michael F Saikali, Liz Bentley, Trevor M Penning, Claes Ohlsson, Carolyn L Cummins, Matti Poutanen, Alex Odermatt, Roger D Cox, Jeremy W Tomlinson
bioRxiv 2021.02.02.429227; doi: https://doi.org/10.1101/2021.02.02.429227
Akr1d1-/- mice have a sexually dimorphic metabolic phenotype with reduced fat mass, increased insulin sensitivity and hypertriglyceridemia in males
Laura L Gathercole, Nikolaos Nikolaou, Anastasia Arvaniti, Shelley E Harris, Toryn M Poolman, Jonathan M Hazlehurst, Denise V Kratschmar, Marijana Todorčević, Ahmad Moolla, Niall Dempster, Ryan C Pink, Michael F Saikali, Liz Bentley, Trevor M Penning, Claes Ohlsson, Carolyn L Cummins, Matti Poutanen, Alex Odermatt, Roger D Cox, Jeremy W Tomlinson
bioRxiv 2021.02.02.429227; doi: https://doi.org/10.1101/2021.02.02.429227
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