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Enhanced genetic analysis of type 1 diabetes by selecting variants on both effect size and significance, and by integration with autoimmune thyroid disease

View ORCID ProfileDaniel J. M. Crouch, View ORCID ProfileJamie R.J. Inshaw, View ORCID ProfileCatherine C. Robertson, Jia-Yuan Zhang, Wei-Min Chen, Suna Onengut-Gumuscu, Antony J. Cutler, Carlo Sidore, Francesco Cucca, Flemming Pociot, Patrick Concannon, Stephen S. Rich, John A. Todd
doi: https://doi.org/10.1101/2021.02.05.429962
Daniel J. M. Crouch
1JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
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  • ORCID record for Daniel J. M. Crouch
Jamie R.J. Inshaw
1JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
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Catherine C. Robertson
2Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
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  • ORCID record for Catherine C. Robertson
Jia-Yuan Zhang
1JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
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Wei-Min Chen
2Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
3Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
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Suna Onengut-Gumuscu
2Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
3Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
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Antony J. Cutler
1JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
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Carlo Sidore
4Institute for Research in Genetics and Biomedicine (IRGB), Sardinia, Italy
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Francesco Cucca
4Institute for Research in Genetics and Biomedicine (IRGB), Sardinia, Italy
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Flemming Pociot
5Department of Pediatrics, Herlev University Hospital, Copenhagen, Denmark
6Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
7Type 1 Diabetes Biology, Department of Clinical Research, Steno Diabetes Center Copenhagen, Gentofte, Denmark
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Patrick Concannon
8Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida, USA
9Genetics Institute, University of Florida, Gainesville, Florida, USA
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Stephen S. Rich
2Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
3Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
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John A. Todd
1JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
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  • For correspondence: jatodd@well.ox.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2021.02.05.429962
History 
  • April 20, 2022.

Article Versions

  • Version 1 (February 6, 2021 - 18:24).
  • Version 2 (February 9, 2021 - 03:24).
  • You are viewing Version 3, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Daniel J. M. Crouch1,
  2. Jamie R.J. Inshaw1,
  3. Catherine C. Robertson2,
  4. Jia-Yuan Zhang1,
  5. Wei-Min Chen2,3,
  6. Suna Onengut-Gumuscu2,3,
  7. Antony J. Cutler1,
  8. Carlo Sidore4,
  9. Francesco Cucca4,
  10. Flemming Pociot5,6,7,
  11. Patrick Concannon8,9,
  12. Stephen S. Rich2,3 and
  13. John A. Todd1,*
  1. 1JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
  2. 2Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
  3. 3Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
  4. 4Institute for Research in Genetics and Biomedicine (IRGB), Sardinia, Italy
  5. 5Department of Pediatrics, Herlev University Hospital, Copenhagen, Denmark
  6. 6Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  7. 7Type 1 Diabetes Biology, Department of Clinical Research, Steno Diabetes Center Copenhagen, Gentofte, Denmark
  8. 8Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida, USA
  9. 9Genetics Institute, University of Florida, Gainesville, Florida, USA
  1. ↵*Corresponding author: John Todd (jatodd{at}well.ox.ac.uk), Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford
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Enhanced genetic analysis of type 1 diabetes by selecting variants on both effect size and significance, and by integration with autoimmune thyroid disease
Daniel J. M. Crouch, Jamie R.J. Inshaw, Catherine C. Robertson, Jia-Yuan Zhang, Wei-Min Chen, Suna Onengut-Gumuscu, Antony J. Cutler, Carlo Sidore, Francesco Cucca, Flemming Pociot, Patrick Concannon, Stephen S. Rich, John A. Todd
bioRxiv 2021.02.05.429962; doi: https://doi.org/10.1101/2021.02.05.429962
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Enhanced genetic analysis of type 1 diabetes by selecting variants on both effect size and significance, and by integration with autoimmune thyroid disease
Daniel J. M. Crouch, Jamie R.J. Inshaw, Catherine C. Robertson, Jia-Yuan Zhang, Wei-Min Chen, Suna Onengut-Gumuscu, Antony J. Cutler, Carlo Sidore, Francesco Cucca, Flemming Pociot, Patrick Concannon, Stephen S. Rich, John A. Todd
bioRxiv 2021.02.05.429962; doi: https://doi.org/10.1101/2021.02.05.429962

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