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Chronic paternal morphine exposure increases sensitivity to morphine-derived antinociception

Andre B. Toussaint, William Foster, Jessica M. Jones, Samuel Kaufmann, Meghan Wachira, Robert Hughes, Angela R. Bongiovanni, Sydney T. Famularo, Benjamin P. Dunham, Ryan Schwark, View ORCID ProfileNathan T. Fried, View ORCID ProfileMathieu E. Wimmer, View ORCID ProfileIshmail Abdus-Saboor
doi: https://doi.org/10.1101/2021.02.07.430143
Andre B. Toussaint
1Department of Psychology, Program in Neuroscience Temple University, Philadelphia, PA, USA
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William Foster
2Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
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Jessica M. Jones
2Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
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Samuel Kaufmann
2Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
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Meghan Wachira
3Departments of Biology, Rutgers Camden University, Camden, NJ, USA
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Robert Hughes
3Departments of Biology, Rutgers Camden University, Camden, NJ, USA
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Angela R. Bongiovanni
1Department of Psychology, Program in Neuroscience Temple University, Philadelphia, PA, USA
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Sydney T. Famularo
1Department of Psychology, Program in Neuroscience Temple University, Philadelphia, PA, USA
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Benjamin P. Dunham
1Department of Psychology, Program in Neuroscience Temple University, Philadelphia, PA, USA
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Ryan Schwark
2Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
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Nathan T. Fried
3Departments of Biology, Rutgers Camden University, Camden, NJ, USA
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  • ORCID record for Nathan T. Fried
Mathieu E. Wimmer
1Department of Psychology, Program in Neuroscience Temple University, Philadelphia, PA, USA
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Ishmail Abdus-Saboor
2Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
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  • ORCID record for Ishmail Abdus-Saboor
  • For correspondence: ishmail@sas.upenn.edu
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Abstract

Parental exposure to drugs of abuse such as opioids can have profound and long-lasting effects on reward processing and drug sensitivity across generations. However, little is known about the impact of long-term paternal exposure to morphine on offspring sensitivity to morphine-derived antinociception during painful experiences. To address this question, we constructed a rat pain scale at millisecond timescales to measure mechanical nociception in a multigenerational morphine exposure paradigm. Surprisingly, while developing the pain scale, we found that von Frey hair filaments (VFHs), the most common stimuli used in pain research, are not painful to rats and morphine did not change the touch-like responses elicited by VFHs. We next deployed this novel pain scale to determine whether chronic morphine exposure in sires impacted pain sensitivity in the next generation. Offspring produced from a cross of morphine-treated sires and drug-naïve dams, did not show any baseline changes in sensitivity to mechanical nociception. However, morphine-sired male progeny displayed a higher sensitivity to the antinociceptive properties of morphine, as measured by our pain scale. These findings demonstrate that long-term paternal exposure to morphine increases sensitivity to morphine-derived analgesia in the subsequent generation.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 08, 2021.
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Chronic paternal morphine exposure increases sensitivity to morphine-derived antinociception
Andre B. Toussaint, William Foster, Jessica M. Jones, Samuel Kaufmann, Meghan Wachira, Robert Hughes, Angela R. Bongiovanni, Sydney T. Famularo, Benjamin P. Dunham, Ryan Schwark, Nathan T. Fried, Mathieu E. Wimmer, Ishmail Abdus-Saboor
bioRxiv 2021.02.07.430143; doi: https://doi.org/10.1101/2021.02.07.430143
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Chronic paternal morphine exposure increases sensitivity to morphine-derived antinociception
Andre B. Toussaint, William Foster, Jessica M. Jones, Samuel Kaufmann, Meghan Wachira, Robert Hughes, Angela R. Bongiovanni, Sydney T. Famularo, Benjamin P. Dunham, Ryan Schwark, Nathan T. Fried, Mathieu E. Wimmer, Ishmail Abdus-Saboor
bioRxiv 2021.02.07.430143; doi: https://doi.org/10.1101/2021.02.07.430143

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