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Intermolecular interactions drive protein adaptive and co-adaptive evolution at both species and population levels

View ORCID ProfileJunhui Peng, View ORCID ProfileLi Zhao
doi: https://doi.org/10.1101/2021.02.08.430345
Junhui Peng
1Laboratory of Evolutionary Genetics and Genomics, The Rockefeller University, New York, NY 10065, USA
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  • ORCID record for Junhui Peng
Li Zhao
1Laboratory of Evolutionary Genetics and Genomics, The Rockefeller University, New York, NY 10065, USA
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  • For correspondence: lzhao@rockefeller.edu
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Abstract

Proteins are the building blocks for almost all the functions in cells. Understanding the molecular evolution of proteins and the forces that shape protein evolution is an essential step in understanding the basis of function and evolution. Previous studies have shown that adaptation occurs frequently at the protein surface, such as in genes involved in host-pathogen interactions. However, it remains unclear whether adaptive sites are distributed randomly or at regions that are associated with particular structural or functional characteristics across the genome, since many of the proteins lack structural or functional annotations. Here, we seek to tackle this question by combining large-scale bioinformatic prediction, structural analysis, phylogenetic inference, and population genomic analysis of Drosophila protein-coding genes. By estimating and comparing the rate of adaptive substitutions at protein and residue level, we showed that adaptation is more relevant to function-related rather than structure-related properties. Among the function-related properties, we found that molecular interactions in proteins contribute to adaptive evolution, and putative binding residues exhibit higher rates of adaptation. We observed that physical interactions might play a role in the co-adaptation of fast-adaptive proteins. We found that strongly differentiated amino acids in protein coding genes are mostly adaptive, which may contribute to the long-term adaptive evolution. Our results suggest important roles of intermolecular interactions and co-adaptation in the adaptive evolution of proteins both at the species and population levels.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted February 10, 2021.
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Intermolecular interactions drive protein adaptive and co-adaptive evolution at both species and population levels
Junhui Peng, Li Zhao
bioRxiv 2021.02.08.430345; doi: https://doi.org/10.1101/2021.02.08.430345
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Intermolecular interactions drive protein adaptive and co-adaptive evolution at both species and population levels
Junhui Peng, Li Zhao
bioRxiv 2021.02.08.430345; doi: https://doi.org/10.1101/2021.02.08.430345

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