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Fluctuations in TCR and pMHC interactions regulate T cell activation

View ORCID ProfileJoseph R. Egan, View ORCID ProfileEnas Abu-Shah, View ORCID ProfileOmer Dushek, View ORCID ProfileTim Elliott, View ORCID ProfileBen D. MacArthur
doi: https://doi.org/10.1101/2021.02.09.430441
Joseph R. Egan
aMathematical Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom
bCentre for Cancer Immunology, University Hospital Southampton, Southampton SO16 6YD, United Kingdom
cInstitute for Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom
dSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
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  • For correspondence: j.r.egan@soton.ac.uk
Enas Abu-Shah
dSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
eKennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom
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Omer Dushek
dSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
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Tim Elliott
bCentre for Cancer Immunology, University Hospital Southampton, Southampton SO16 6YD, United Kingdom
cInstitute for Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom
fNuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom
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Ben D. MacArthur
aMathematical Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom
cInstitute for Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom
gCentre for Human Development, Stem Cells and Regeneration, University of Southampton, Southampton SO17 1BJ, United Kingdom
hAlan Turing Institute, London NW1 2DB, United Kingdom
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Article Information

doi 
https://doi.org/10.1101/2021.02.09.430441
History 
  • July 5, 2021.

Article Versions

  • Version 1 (February 10, 2021 - 23:12).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Joseph R. Egana,b,c,d,*,
  2. Enas Abu-Shahd,e,
  3. Omer Dushekd,
  4. Tim Elliottb,c,f and
  5. Ben D. MacArthura,c,g,h
  1. aMathematical Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom
  2. bCentre for Cancer Immunology, University Hospital Southampton, Southampton SO16 6YD, United Kingdom
  3. cInstitute for Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom
  4. dSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
  5. eKennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom
  6. fNuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom
  7. gCentre for Human Development, Stem Cells and Regeneration, University of Southampton, Southampton SO17 1BJ, United Kingdom
  8. hAlan Turing Institute, London NW1 2DB, United Kingdom
  1. ↵* Corresponding author; email: j.r.egan{at}soton.ac.uk
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Posted July 05, 2021.
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Fluctuations in TCR and pMHC interactions regulate T cell activation
Joseph R. Egan, Enas Abu-Shah, Omer Dushek, Tim Elliott, Ben D. MacArthur
bioRxiv 2021.02.09.430441; doi: https://doi.org/10.1101/2021.02.09.430441
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Fluctuations in TCR and pMHC interactions regulate T cell activation
Joseph R. Egan, Enas Abu-Shah, Omer Dushek, Tim Elliott, Ben D. MacArthur
bioRxiv 2021.02.09.430441; doi: https://doi.org/10.1101/2021.02.09.430441

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