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Single paternal Dexamethasone challenge programs offspring metabolism and reveals circRNAs as novel candidates in RNA-mediated inheritance

View ORCID ProfileKatharina Gapp, Guillermo Parada, Fridolin Gross, Alberto Corcoba, Evelyn Grau, Martin Hemberg, Johannes Bohacek, Eric A. Miska
doi: https://doi.org/10.1101/2021.02.10.429888
Katharina Gapp
1Gurdon Institute, University of Cambridge, Tennis Court Rd, Cambridge, CB2 1QN, UK.
2Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
3Institute for Neuroscience, Department of Health Science Technology, ETH Zürich, Winterthurerstr. 190, 8057 Zürich, Switzerland
4Neuroscience Center Zurich, ETH Zurich and University of Zurich, Switzerland
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  • ORCID record for Katharina Gapp
Guillermo Parada
1Gurdon Institute, University of Cambridge, Tennis Court Rd, Cambridge, CB2 1QN, UK.
2Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
5Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK
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Fridolin Gross
3Institute for Neuroscience, Department of Health Science Technology, ETH Zürich, Winterthurerstr. 190, 8057 Zürich, Switzerland
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Alberto Corcoba
2Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
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Evelyn Grau
2Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
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Martin Hemberg
1Gurdon Institute, University of Cambridge, Tennis Court Rd, Cambridge, CB2 1QN, UK.
2Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
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Johannes Bohacek
3Institute for Neuroscience, Department of Health Science Technology, ETH Zürich, Winterthurerstr. 190, 8057 Zürich, Switzerland
4Neuroscience Center Zurich, ETH Zurich and University of Zurich, Switzerland
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Eric A. Miska
1Gurdon Institute, University of Cambridge, Tennis Court Rd, Cambridge, CB2 1QN, UK.
2Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
5Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK
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Article Information

doi 
https://doi.org/10.1101/2021.02.10.429888
History 
  • March 10, 2021.

Article Versions

  • Version 1 (February 10, 2021 - 23:00).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.

Author Information

  1. Katharina Gapp#,1,2,3,4,
  2. Guillermo Parada1,2,5,
  3. Fridolin Gross3,
  4. Alberto Corcoba2,
  5. Evelyn Grau2,
  6. Martin Hemberg1,2,
  7. Johannes Bohacek3,4 and
  8. Eric A. Miska*,1,2,5
  1. 1Gurdon Institute, University of Cambridge, Tennis Court Rd, Cambridge, CB2 1QN, UK.
  2. 2Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK
  3. 3Institute for Neuroscience, Department of Health Science Technology, ETH Zürich, Winterthurerstr. 190, 8057 Zürich, Switzerland
  4. 4Neuroscience Center Zurich, ETH Zurich and University of Zurich, Switzerland
  5. 5Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK
  1. ↵*corresponding
  2. ↵#co-corresponding author
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Posted March 10, 2021.
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Single paternal Dexamethasone challenge programs offspring metabolism and reveals circRNAs as novel candidates in RNA-mediated inheritance
Katharina Gapp, Guillermo Parada, Fridolin Gross, Alberto Corcoba, Evelyn Grau, Martin Hemberg, Johannes Bohacek, Eric A. Miska
bioRxiv 2021.02.10.429888; doi: https://doi.org/10.1101/2021.02.10.429888
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Single paternal Dexamethasone challenge programs offspring metabolism and reveals circRNAs as novel candidates in RNA-mediated inheritance
Katharina Gapp, Guillermo Parada, Fridolin Gross, Alberto Corcoba, Evelyn Grau, Martin Hemberg, Johannes Bohacek, Eric A. Miska
bioRxiv 2021.02.10.429888; doi: https://doi.org/10.1101/2021.02.10.429888

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