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Relation of inflammatory marker trajectories with frailty and aging in a 20-year longitudinal study

View ORCID ProfileLeonard Daniël Samson, Anne-Marie Buisman, José A. Ferreira, H. Susan J. Picavet, W. M. Monique Verschuren, A. Mieke H. Boots, Peter Engelfriet
doi: https://doi.org/10.1101/2021.02.10.430670
Leonard Daniël Samson
1National Institute of Public Health and the Environment, Bilthoven, The Netherlands
2Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands
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  • ORCID record for Leonard Daniël Samson
  • For correspondence: leon.samson@rivm.nl
Anne-Marie Buisman
1National Institute of Public Health and the Environment, Bilthoven, The Netherlands
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José A. Ferreira
1National Institute of Public Health and the Environment, Bilthoven, The Netherlands
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H. Susan J. Picavet
1National Institute of Public Health and the Environment, Bilthoven, The Netherlands
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W. M. Monique Verschuren
1National Institute of Public Health and the Environment, Bilthoven, The Netherlands
3Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
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A. Mieke H. Boots
2Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands
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Peter Engelfriet
1National Institute of Public Health and the Environment, Bilthoven, The Netherlands
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Abstract

Little is known about the development of low-grade inflammation with age and its relationship with the onset of frailty. In this exploratory study, we investigated 18 inflammatory markers measured in blood of 144 individuals aged 65-75 years at study endpoint, collected over 20 years at five-year intervals. IFNγ-induced markers and platelet activation markers changed in synchrony over time. Chronically elevated levels of IL-6-related markers, such as CRP and sIL-6R, were associated with frailty and becoming frail over time, poorer lung function, or less physical strength. Overweight was a possible driver of these associations. More and stronger associations were detected in women, such as between increasing sCD14 levels and frailty, indicating possible monocyte overactivation. Multivariate prediction of frailty showed low accuracy but confirmed the main results. In summary, we documented 20-year temporal changes of inflammatory markers in an aging population, and related these to clinically relevant health outcomes.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 12, 2021.
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Relation of inflammatory marker trajectories with frailty and aging in a 20-year longitudinal study
Leonard Daniël Samson, Anne-Marie Buisman, José A. Ferreira, H. Susan J. Picavet, W. M. Monique Verschuren, A. Mieke H. Boots, Peter Engelfriet
bioRxiv 2021.02.10.430670; doi: https://doi.org/10.1101/2021.02.10.430670
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Relation of inflammatory marker trajectories with frailty and aging in a 20-year longitudinal study
Leonard Daniël Samson, Anne-Marie Buisman, José A. Ferreira, H. Susan J. Picavet, W. M. Monique Verschuren, A. Mieke H. Boots, Peter Engelfriet
bioRxiv 2021.02.10.430670; doi: https://doi.org/10.1101/2021.02.10.430670

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