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Small intestine lactobacilli growth promotion and immunomodulation in weaner pigs fed Cyberlindnera jadinii yeast high inclusion diet and exposed to enterotoxigenic Escherichia coli F4+: O149

View ORCID ProfileS. Iakhno, S.S. Hellestveit, View ORCID ProfileÖ.C.O. Umu, L.T. Bogevik, View ORCID ProfileC.P. Åkesson, A.B. Göksu, View ORCID ProfileC.McL. Press, View ORCID ProfileL.T. Mydland, View ORCID ProfileM. Øverland, H. Sørum
doi: https://doi.org/10.1101/2021.02.11.430732
S. Iakhno
1Department of Paraclinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway
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  • For correspondence: stanislav.iakhno@gmail.com
S.S. Hellestveit
2Department of Preclinical and Pathological, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway
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Ö.C.O. Umu
1Department of Paraclinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway
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L.T. Bogevik
3Norsvin R&D, Storhamargata 44, 2317 Hamar, Norway
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C.P. Åkesson
2Department of Preclinical and Pathological, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway
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A.B. Göksu
2Department of Preclinical and Pathological, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway
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C.McL. Press
2Department of Preclinical and Pathological, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway
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L.T. Mydland
4Faculty of Biosciences, Norwegian University of Life Sciences, Ås, Norway
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M. Øverland
4Faculty of Biosciences, Norwegian University of Life Sciences, Ås, Norway
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H. Sørum
1Department of Paraclinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway
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1 Abstract

Enterotoxigenic Escherichia coli (ETEC) F4+: O149 is a causative agent for the development of post-weaning diarrhoea (PWD) in pigs that contributes to production losses. Yeast cell wall components used as a feed additive can modulate gut immunity and help protect animals from enteric infections. This work investigated how a novel yeast diet with high inclusion of yeast proteins (40% of crude protein) affected the course of ETEC mediated diarrhoea in weaner piglets from a farm with or without a history of post-weaning diarrhoea. We found that immune response to F4ab ETEC infection and appetite of the animals were altered by high inclusion C. jadinii yeast. The results indicate that the novel diet can support the diseased animals either directly through the effect of yeast beta-glucans and mannans or indirectly through the promotion of small intestine lactobacilli or both.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 11, 2021.
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Small intestine lactobacilli growth promotion and immunomodulation in weaner pigs fed Cyberlindnera jadinii yeast high inclusion diet and exposed to enterotoxigenic Escherichia coli F4+: O149
S. Iakhno, S.S. Hellestveit, Ö.C.O. Umu, L.T. Bogevik, C.P. Åkesson, A.B. Göksu, C.McL. Press, L.T. Mydland, M. Øverland, H. Sørum
bioRxiv 2021.02.11.430732; doi: https://doi.org/10.1101/2021.02.11.430732
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Small intestine lactobacilli growth promotion and immunomodulation in weaner pigs fed Cyberlindnera jadinii yeast high inclusion diet and exposed to enterotoxigenic Escherichia coli F4+: O149
S. Iakhno, S.S. Hellestveit, Ö.C.O. Umu, L.T. Bogevik, C.P. Åkesson, A.B. Göksu, C.McL. Press, L.T. Mydland, M. Øverland, H. Sørum
bioRxiv 2021.02.11.430732; doi: https://doi.org/10.1101/2021.02.11.430732

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