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Revealing the Physiological Origin of Event-Related Potentials using Electrocorticography in Humans

View ORCID ProfileHohyun Cho, View ORCID ProfileGerwin Schalk, View ORCID ProfileMarkus Adamek, Ladan Moheimanian, William G. Coon, Sung Chan Jun, Jonathan R. Wolpaw, View ORCID ProfilePeter Brunner
doi: https://doi.org/10.1101/2021.02.12.430921
Hohyun Cho
1National Center for Adaptive Neurotechnologies, Albany, NY 12208, USA
2Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, 12208, USA
3Department of Neurosurgery, Washington University School of Medicine, St. Louis 63110, MO, USA
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Gerwin Schalk
1National Center for Adaptive Neurotechnologies, Albany, NY 12208, USA
4Department of Biomedical Science, School of Public Health, State University of New York, Albany, NY 12222, USA
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Markus Adamek
1National Center for Adaptive Neurotechnologies, Albany, NY 12208, USA
5Department of Neuroscience, Washington University School of Medicine, St. Louis 63110, MO, USA
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Ladan Moheimanian
1National Center for Adaptive Neurotechnologies, Albany, NY 12208, USA
4Department of Biomedical Science, School of Public Health, State University of New York, Albany, NY 12222, USA
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William G. Coon
6Applied Physics Laboratory, Johns Hopkins University, Baltimore, MD 21218, USA
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Sung Chan Jun
7School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, Gwangju 61005, South Korea
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Jonathan R. Wolpaw
1National Center for Adaptive Neurotechnologies, Albany, NY 12208, USA
4Department of Biomedical Science, School of Public Health, State University of New York, Albany, NY 12222, USA
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Peter Brunner
1National Center for Adaptive Neurotechnologies, Albany, NY 12208, USA
2Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, 12208, USA
3Department of Neurosurgery, Washington University School of Medicine, St. Louis 63110, MO, USA
8Department of Neurology, Albany Medical College, Albany 12208, NY, USA
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  • For correspondence: brunner@neurotechcenter.org
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Abstract

The scientific and clinical value of event-related potentials (ERPs) depends on understanding the contributions to them of three possible mechanisms: (1) additivity of time-locked voltage changes; (2) phase resetting of ongoing oscillations; (3) asymmetrical oscillatory activity. Their relative contributions are currently uncertain. This study uses analysis of human electrocorticographic activity to quantify the origins of movement-related potentials (MRPs) and auditory evoked potentials (AEPs). The results show that MRPs are generated primarily by endogenous additivity (88%). In contrast, P1 and N1 components of AEPs are generated almost entirely by exogenous phase reset (93%). Oscillatory asymmetry contributes very little. By clarifying ERP mechanisms, these results enable creation of ERP models; and they enhance the value of ERPs for understanding the genesis of normal and abnormal auditory or sensorimotor behaviors.

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Posted February 14, 2021.
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Revealing the Physiological Origin of Event-Related Potentials using Electrocorticography in Humans
Hohyun Cho, Gerwin Schalk, Markus Adamek, Ladan Moheimanian, William G. Coon, Sung Chan Jun, Jonathan R. Wolpaw, Peter Brunner
bioRxiv 2021.02.12.430921; doi: https://doi.org/10.1101/2021.02.12.430921
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Revealing the Physiological Origin of Event-Related Potentials using Electrocorticography in Humans
Hohyun Cho, Gerwin Schalk, Markus Adamek, Ladan Moheimanian, William G. Coon, Sung Chan Jun, Jonathan R. Wolpaw, Peter Brunner
bioRxiv 2021.02.12.430921; doi: https://doi.org/10.1101/2021.02.12.430921

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