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Mutation N501Y in RBD of Spike Protein Strengthens the Interaction between COVID-19 and its Receptor ACE2

Fang Tian, Bei Tong, Liang Sun, Shengchao Shi, Bin Zheng, Zibin Wang, Xianchi Dong, View ORCID ProfilePeng Zheng
doi: https://doi.org/10.1101/2021.02.14.431117
Fang Tian
1State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023, China
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Bei Tong
2Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, 210014, China
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  • For correspondence: pengz@nju.edu.cn beitong@cnbg.net xianchidong@nju.edu.cn
Liang Sun
3State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, China
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Shengchao Shi
1State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023, China
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Bin Zheng
1State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023, China
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Zibin Wang
3State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, China
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Xianchi Dong
3State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, China
4Engineering Research Center of Protein and Peptide Medicine, Ministry of Education, China
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  • For correspondence: pengz@nju.edu.cn beitong@cnbg.net xianchidong@nju.edu.cn
Peng Zheng
1State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023, China
4Engineering Research Center of Protein and Peptide Medicine, Ministry of Education, China
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  • ORCID record for Peng Zheng
  • For correspondence: pengz@nju.edu.cn beitong@cnbg.net xianchidong@nju.edu.cn
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Article Information

doi 
https://doi.org/10.1101/2021.02.14.431117
History 
  • February 15, 2021.

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  • You are currently viewing Version 1 of this article (February 15, 2021 - 12:51).
  • View Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.

Author Information

  1. Fang Tian1,#,
  2. Bei Tong2,#,*,
  3. Liang Sun3,
  4. Shengchao Shi1,
  5. Bin Zheng1,
  6. Zibin Wang3,
  7. Xianchi Dong3,4,* and
  8. Peng Zheng1,4,*
  1. 1State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023, China
  2. 2Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, 210014, China
  3. 3State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, China
  4. 4Engineering Research Center of Protein and Peptide Medicine, Ministry of Education, China
  1. ↵*Corresponding authors: pengz{at}nju.edu.cn, beitong{at}cnbg.net, and xianchidong{at}nju.edu.cn
  1. ↵# These authors contributed equally to this work

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Posted February 15, 2021.
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Mutation N501Y in RBD of Spike Protein Strengthens the Interaction between COVID-19 and its Receptor ACE2
Fang Tian, Bei Tong, Liang Sun, Shengchao Shi, Bin Zheng, Zibin Wang, Xianchi Dong, Peng Zheng
bioRxiv 2021.02.14.431117; doi: https://doi.org/10.1101/2021.02.14.431117
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Mutation N501Y in RBD of Spike Protein Strengthens the Interaction between COVID-19 and its Receptor ACE2
Fang Tian, Bei Tong, Liang Sun, Shengchao Shi, Bin Zheng, Zibin Wang, Xianchi Dong, Peng Zheng
bioRxiv 2021.02.14.431117; doi: https://doi.org/10.1101/2021.02.14.431117

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