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In vitro efficacy of Artemisia extracts against SARS-CoV-2

Chuanxiong Nie, Jakob Trimpert, Sooyeon Moon, Rainer Haag, Kerry Gilmore, Benedikt B. Kaufer, View ORCID ProfilePeter H. Seeberger
doi: https://doi.org/10.1101/2021.02.14.431122
Chuanxiong Nie
1Freie Universität Berlin, Institute for Virology, Robert von Ostertag-Str. 7-13, 14163 Berlin, Germany
2Freie Universität Berlin, Department of Chemistry and Biochemistry, Takustrasse 3, 14195 Berlin, Germany
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Jakob Trimpert
1Freie Universität Berlin, Institute for Virology, Robert von Ostertag-Str. 7-13, 14163 Berlin, Germany
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Sooyeon Moon
3Max-Planck Institute for Colloids and Interfaces, Department for Biomolecular Systems; Am Mühlenberg 1, 14476 Potsdam, Germany
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Rainer Haag
2Freie Universität Berlin, Department of Chemistry and Biochemistry, Takustrasse 3, 14195 Berlin, Germany
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Kerry Gilmore
3Max-Planck Institute for Colloids and Interfaces, Department for Biomolecular Systems; Am Mühlenberg 1, 14476 Potsdam, Germany
4Department of Chemistry, University of Connecticut, 55 N. Eagleville rd. Storrs, CT, USA 06268
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Benedikt B. Kaufer
1Freie Universität Berlin, Institute for Virology, Robert von Ostertag-Str. 7-13, 14163 Berlin, Germany
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  • For correspondence: peter.seeberger@mpikg.mpg.de Benedikt.Kaufer@fu-berlin.de
Peter H. Seeberger
2Freie Universität Berlin, Department of Chemistry and Biochemistry, Takustrasse 3, 14195 Berlin, Germany
3Max-Planck Institute for Colloids and Interfaces, Department for Biomolecular Systems; Am Mühlenberg 1, 14476 Potsdam, Germany
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  • ORCID record for Peter H. Seeberger
  • For correspondence: peter.seeberger@mpikg.mpg.de Benedikt.Kaufer@fu-berlin.de
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Abstract

Traditional medicines based on herbal extracts have been proposed as affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Teas and drinks containing extracts of Artemisia annua and Artemisia afra have been widely used in Africa in efforts to prevent and fight COVID-19 infections. We sought to study the ability of different A. annua and A. afra extracts and the Covid-Organics drink produced in Madagascar to inhibit SARS-CoV-2 and feline coronavirus (FCoV) replication in vitro. Several extracts as well as Covid-Organics inhibit SARS-CoV-2 and FCoV replication at concentrations that did not affect cell viability. It remains unclear whether peak plasma concentrations in humans can reach levels needed to inhibit viral replication following consumption of teas or Covid-Organics. Clinical studies are required to evaluate the utility of these drinks for COVID-19 prevention or treatment in patients.

Competing Interest Statement

K.G. is the director of ArtemiLife, Inc. K.G. and P.H.S. have a significant financial stake in ArtemiFlow GmbH, that is a shareholder in ArtemiLife, Inc. All other authors have no competing/conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted February 15, 2021.
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In vitro efficacy of Artemisia extracts against SARS-CoV-2
Chuanxiong Nie, Jakob Trimpert, Sooyeon Moon, Rainer Haag, Kerry Gilmore, Benedikt B. Kaufer, Peter H. Seeberger
bioRxiv 2021.02.14.431122; doi: https://doi.org/10.1101/2021.02.14.431122
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In vitro efficacy of Artemisia extracts against SARS-CoV-2
Chuanxiong Nie, Jakob Trimpert, Sooyeon Moon, Rainer Haag, Kerry Gilmore, Benedikt B. Kaufer, Peter H. Seeberger
bioRxiv 2021.02.14.431122; doi: https://doi.org/10.1101/2021.02.14.431122

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