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Parasite co-opts a ubiquitin receptor to induce a plethora of developmental changes

View ORCID ProfileWeijie Huang, View ORCID ProfileAllyson M. MacLean, Akiko Sugio, Abbas Maqbool, Marco Busscher, Shu-Ting Cho, View ORCID ProfileSophien Kamoun, View ORCID ProfileChih-Horng Kuo, Richard G.H. Immink, Saskia A. Hogenhout
doi: https://doi.org/10.1101/2021.02.15.430920
Weijie Huang
1Department of Crop Genetics, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK
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  • ORCID record for Weijie Huang
Allyson M. MacLean
1Department of Crop Genetics, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK
6Current address: Department of Biology, University of Ottawa, Ottawa ON, K1N 6N5, Canada
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Akiko Sugio
1Department of Crop Genetics, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK
7Institute of Genetics, Environment and Plant Protection, INRAE, Le Rheu, 35650, France
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Abbas Maqbool
2The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, NR4 7UH, UK
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Marco Busscher
3Laboratory of Molecular Biology, Wageningen University and Research, Wageningen, 6708 PB, The Netherlands
4Plant Developmental Systems, Bioscience, Wageningen University and Research, Wageningen, 6708PB, The Netherlands
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Shu-Ting Cho
5Institute of Plant and Microbial Biology, Academia Sinica, Taipei, 11529, Taiwan
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Sophien Kamoun
2The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, NR4 7UH, UK
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  • ORCID record for Sophien Kamoun
Chih-Horng Kuo
5Institute of Plant and Microbial Biology, Academia Sinica, Taipei, 11529, Taiwan
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Richard G.H. Immink
3Laboratory of Molecular Biology, Wageningen University and Research, Wageningen, 6708 PB, The Netherlands
4Plant Developmental Systems, Bioscience, Wageningen University and Research, Wageningen, 6708PB, The Netherlands
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Saskia A. Hogenhout
1Department of Crop Genetics, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK
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  • For correspondence: saskia.hogenhout@jic.ac.uk
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Abstract

Obligate parasites can induce complex and substantial phenotypic changes in their hosts in ways that favour their transmission to other trophic levels. However, mechanisms underlying these changes remain largely unknown. Here, we demonstrate how SAP05 protein effectors from insect-vectored plant pathogenic phytoplasmas take control of several plant developmental processes to simultaneously prolong host lifespan and induce witch’s broom-like proliferations of leaf and sterile shoots, organs colonized by phytoplasmas and vectors. SAP05 acts by mediating the concurrent degradation of SPL and GATA developmental regulators via a process that uniquely relies on hijacking the plant ubiquitin receptor RPN10 independently of substrate lysine ubiquitination. RPN10 is highly conserved among eukaryotes, but SAP05 does not bind insect vector RPN10. A two-amino-acid substitution within plant RPN10 generates a functional variant that is resistant to SAP05 activities. Therefore, one effector protein enables obligate parasitic phytoplasmas to induce a plethora of developmental phenotypes in their hosts.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 15, 2021.
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Parasite co-opts a ubiquitin receptor to induce a plethora of developmental changes
Weijie Huang, Allyson M. MacLean, Akiko Sugio, Abbas Maqbool, Marco Busscher, Shu-Ting Cho, Sophien Kamoun, Chih-Horng Kuo, Richard G.H. Immink, Saskia A. Hogenhout
bioRxiv 2021.02.15.430920; doi: https://doi.org/10.1101/2021.02.15.430920
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Parasite co-opts a ubiquitin receptor to induce a plethora of developmental changes
Weijie Huang, Allyson M. MacLean, Akiko Sugio, Abbas Maqbool, Marco Busscher, Shu-Ting Cho, Sophien Kamoun, Chih-Horng Kuo, Richard G.H. Immink, Saskia A. Hogenhout
bioRxiv 2021.02.15.430920; doi: https://doi.org/10.1101/2021.02.15.430920

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