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501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to Bamlanivimab in vitro

Haolin Liu, Pengcheng Wei, Qianqian Zhang, Zhongzhou Chen, Katja Aviszus, Walter Downing, Shelley Peterson, Lyndon Reynoso, Gregory P. Downey, Stephen K. Frankel, John Kappler, Philippa Marrack, Gongyi Zhang
doi: https://doi.org/10.1101/2021.02.16.431305
Haolin Liu
1Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA and Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO 80216, USA
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  • For correspondence: Liuh@NJhealth.org Marrackp@NJhealth.org Zhangg@NJhealth.org
Pengcheng Wei
1Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA and Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO 80216, USA
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Qianqian Zhang
2State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agriculture University, Beijing 100193, People’s Republic of China
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Zhongzhou Chen
2State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agriculture University, Beijing 100193, People’s Republic of China
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Katja Aviszus
1Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA and Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO 80216, USA
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Walter Downing
3Department of Nursing, National Jewish Health, Denver, CO80206, USA
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Shelley Peterson
3Department of Nursing, National Jewish Health, Denver, CO80206, USA
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Lyndon Reynoso
4Department of Pharmacy, National Jewish Health, Denver, CO80206, USA
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Gregory P. Downey
5Department of Medicine, National Jewish Health, Denver, CO 80206, USA
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Stephen K. Frankel
5Department of Medicine, National Jewish Health, Denver, CO 80206, USA
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John Kappler
1Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA and Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO 80216, USA
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Philippa Marrack
1Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA and Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO 80216, USA
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  • For correspondence: Liuh@NJhealth.org Marrackp@NJhealth.org Zhangg@NJhealth.org
Gongyi Zhang
1Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA and Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO 80216, USA
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  • For correspondence: Liuh@NJhealth.org Marrackp@NJhealth.org Zhangg@NJhealth.org
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Article Information

doi 
https://doi.org/10.1101/2021.02.16.431305
History 
  • February 16, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Haolin Liu1,#,
  2. Pengcheng Wei1,
  3. Qianqian Zhang2,
  4. Zhongzhou Chen2,
  5. Katja Aviszus1,
  6. Walter Downing3,
  7. Shelley Peterson3,
  8. Lyndon Reynoso4,
  9. Gregory P. Downey5,
  10. Stephen K. Frankel5,
  11. John Kappler1,
  12. Philippa Marrack1,# and
  13. Gongyi Zhang1,#
  1. 1Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA and Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO 80216, USA
  2. 2State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agriculture University, Beijing 100193, People’s Republic of China
  3. 3Department of Nursing, National Jewish Health, Denver, CO80206, USA
  4. 4Department of Pharmacy, National Jewish Health, Denver, CO80206, USA
  5. 5Department of Medicine, National Jewish Health, Denver, CO 80206, USA
  1. ↵#Correspondents: Liuh{at}NJhealth.org, Marrackp{at}NJhealth.org, Zhangg{at}NJhealth.org
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Posted February 16, 2021.
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501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to Bamlanivimab in vitro
Haolin Liu, Pengcheng Wei, Qianqian Zhang, Zhongzhou Chen, Katja Aviszus, Walter Downing, Shelley Peterson, Lyndon Reynoso, Gregory P. Downey, Stephen K. Frankel, John Kappler, Philippa Marrack, Gongyi Zhang
bioRxiv 2021.02.16.431305; doi: https://doi.org/10.1101/2021.02.16.431305
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501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to Bamlanivimab in vitro
Haolin Liu, Pengcheng Wei, Qianqian Zhang, Zhongzhou Chen, Katja Aviszus, Walter Downing, Shelley Peterson, Lyndon Reynoso, Gregory P. Downey, Stephen K. Frankel, John Kappler, Philippa Marrack, Gongyi Zhang
bioRxiv 2021.02.16.431305; doi: https://doi.org/10.1101/2021.02.16.431305

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