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Shared functional connections within and between cortical networks predict individual cognitive abilities in adult males and females

View ORCID ProfileElvisha Dhamala, View ORCID ProfileKeith W. Jamison, View ORCID ProfileAbhishek Jaywant, View ORCID ProfileAmy Kuceyeski
doi: https://doi.org/10.1101/2021.02.17.431670
Elvisha Dhamala
1Department of Radiology, Weill Cornell Medicine, New York, NY, USA, 10065
2Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA, 10065
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  • For correspondence: elvisha@gmail.com amk2012@med.cornell.edu
Keith W. Jamison
1Department of Radiology, Weill Cornell Medicine, New York, NY, USA, 10065
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Abhishek Jaywant
3Department of Psychiatry, Weill Cornell Medicine, New York, NY, USA, 10065
4Department of Rehabilitation Medicine, Weill Cornell Medicine, New York, NY, USA, 10065
5NewYork-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY, USA, 10065
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Amy Kuceyeski
1Department of Radiology, Weill Cornell Medicine, New York, NY, USA, 10065
2Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA, 10065
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  • For correspondence: elvisha@gmail.com amk2012@med.cornell.edu
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Abstract

A thorough understanding of sex-independent and sex-specific neurobiological features that underlie cognitive abilities in healthy individuals is essential for the study of neurological illnesses in which males and females differentially experience and exhibit cognitive impairment. Here, we evaluate sex-independent and sex-specific relationships between functional connectivity and individual cognitive abilities in 392 healthy young adults (196 males) from the Human Connectome Project. First, we establish that sex-independent models comparably predict crystallised abilities in males and females, but more accurately predict fluid abilities in males. Second, we demonstrate sex-specific models comparably predict crystallised abilities within and between sexes, and generally fail to predict fluid abilities in either sex. Third, we reveal that largely overlapping connections between visual, dorsal attention, ventral attention, and temporal parietal networks are associated with better performance on crystallised and fluid cognitive tests in males and females, while connections within visual, somatomotor, and temporal parietal networks are associated with poorer performance. Together, our findings suggest that shared neurobiological features of the functional connectome underlie crystallised and fluid abilities across the sexes.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 06, 2021.
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Shared functional connections within and between cortical networks predict individual cognitive abilities in adult males and females
Elvisha Dhamala, Keith W. Jamison, Abhishek Jaywant, Amy Kuceyeski
bioRxiv 2021.02.17.431670; doi: https://doi.org/10.1101/2021.02.17.431670
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Shared functional connections within and between cortical networks predict individual cognitive abilities in adult males and females
Elvisha Dhamala, Keith W. Jamison, Abhishek Jaywant, Amy Kuceyeski
bioRxiv 2021.02.17.431670; doi: https://doi.org/10.1101/2021.02.17.431670

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