ABSTRACT
Ever since the breakout of COVID-19 disease, ceaseless genomic research to inspect the epidemiology and evolution of the pathogen has been undertaken globally. Large scale viral genome sequencing and analysis have uncovered the functional impact of numerous genetic variants in disease pathogenesis and transmission. Emerging evidence of mutations in spike protein domains escaping antibody neutralization is reported. We have built a database with precise collation of manually curated variants in SARS-CoV-2 from literature with potential escape mechanisms from a range of neutralizing antibodies. This comprehensive repository encompasses a total of 5258 variants accounting for 2068 unique variants tested against 230 antibodies, patient convalescent plasma and vaccine breakthrough events. This resource enables the user to gain access to an extensive annotation of SARS-CoV-2 escape variants which would contribute to exploring and understanding the underlying mechanisms of immune response against the pathogen. The resource is available at http://clingen.igib.res.in/esc/
Competing Interest Statement
The authors have declared no competing interest.
Footnotes
Email of authors Mercy Rophina: mercy.rophina{at}igib.res.in; Kavita Pandhare: pandharekavita{at}gmail.com; Afra Shamnath: afrashamnath230896{at}gmail.com; Mohamed Imran:mhdimr.s{at}gmail.com; Bani Jolly:banijolly1995{at}gmail.com
The updated features of ESC database has been highlighted in the revised version of the manuscript