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Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
View ORCID ProfileCarly G. K. Ziegler, Vincent N. Miao, Anna H. Owings, Andrew W. Navia, Ying Tang, Joshua D. Bromley, Peter Lotfy, Meredith Sloan, Hannah Laird, Haley B. Williams, Micayla George, Riley S. Drake, Taylor Christian, Adam Parker, Campbell B. Sindel, Molly W. Burger, Yilianys Pride, Mohammad Hasan, George E. Abraham III, Michal Senitko, Tanya O. Robinson, View ORCID ProfileAlex K. Shalek, Sarah C. Glover, Bruce H. Horwitz, View ORCID ProfileJose Ordovas-Montanes
doi: https://doi.org/10.1101/2021.02.20.431155
Carly G. K. Ziegler
1Program in Health Sciences & Technology, Harvard Medical School & MIT, Boston, MA 02115, USA
2Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
3Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
4Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA 02138, USA
5Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Vincent N. Miao
1Program in Health Sciences & Technology, Harvard Medical School & MIT, Boston, MA 02115, USA
2Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
3Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Anna H. Owings
6Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
Andrew W. Navia
2Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
3Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
7Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Ying Tang
8Division of Gastroenterology, Hepatology, and Nutrition, Boston Children’s Hospital, Boston, MA 02115, USA
Joshua D. Bromley
2Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
3Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
9Department of Microbiology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Peter Lotfy
3Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
8Division of Gastroenterology, Hepatology, and Nutrition, Boston Children’s Hospital, Boston, MA 02115, USA
Meredith Sloan
6Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
Hannah Laird
10Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, USA
Haley B. Williams
10Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, USA
Micayla George
2Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
3Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Riley S. Drake
2Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
3Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Taylor Christian
6Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
Adam Parker
10Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, USA
Campbell B. Sindel
11Division of Pulmonary, Critical Care, and Sleep Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
Molly W. Burger
12Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216, USA
Yilianys Pride
10Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, USA
Mohammad Hasan
10Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, USA
George E. Abraham III
11Division of Pulmonary, Critical Care, and Sleep Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
Michal Senitko
11Division of Pulmonary, Critical Care, and Sleep Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
Tanya O. Robinson
10Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, USA
Alex K. Shalek
1Program in Health Sciences & Technology, Harvard Medical School & MIT, Boston, MA 02115, USA
2Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
3Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
4Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA 02138, USA
5Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
7Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
13Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
15Program in Immunology, Harvard Medical School, Boston, MA 02115, USA
16Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Sarah C. Glover
10Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, USA
Bruce H. Horwitz
8Division of Gastroenterology, Hepatology, and Nutrition, Boston Children’s Hospital, Boston, MA 02115, USA
14Division of Emergency Medicine, Boston Children’s Hospital, Boston, MA 02115, USA
15Program in Immunology, Harvard Medical School, Boston, MA 02115, USA
Jose Ordovas-Montanes
3Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
8Division of Gastroenterology, Hepatology, and Nutrition, Boston Children’s Hospital, Boston, MA 02115, USA
15Program in Immunology, Harvard Medical School, Boston, MA 02115, USA
16Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Article usage
Posted February 20, 2021.
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
Carly G. K. Ziegler, Vincent N. Miao, Anna H. Owings, Andrew W. Navia, Ying Tang, Joshua D. Bromley, Peter Lotfy, Meredith Sloan, Hannah Laird, Haley B. Williams, Micayla George, Riley S. Drake, Taylor Christian, Adam Parker, Campbell B. Sindel, Molly W. Burger, Yilianys Pride, Mohammad Hasan, George E. Abraham III, Michal Senitko, Tanya O. Robinson, Alex K. Shalek, Sarah C. Glover, Bruce H. Horwitz, Jose Ordovas-Montanes
bioRxiv 2021.02.20.431155; doi: https://doi.org/10.1101/2021.02.20.431155
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
Carly G. K. Ziegler, Vincent N. Miao, Anna H. Owings, Andrew W. Navia, Ying Tang, Joshua D. Bromley, Peter Lotfy, Meredith Sloan, Hannah Laird, Haley B. Williams, Micayla George, Riley S. Drake, Taylor Christian, Adam Parker, Campbell B. Sindel, Molly W. Burger, Yilianys Pride, Mohammad Hasan, George E. Abraham III, Michal Senitko, Tanya O. Robinson, Alex K. Shalek, Sarah C. Glover, Bruce H. Horwitz, Jose Ordovas-Montanes
bioRxiv 2021.02.20.431155; doi: https://doi.org/10.1101/2021.02.20.431155
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