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Nanoceutical Fabric Prevents COVID-19 Spread through Expelled Respiratory Droplets: A Combined Computational, Spectroscopic and Anti-microbial Study

View ORCID ProfileAniruddha Adhikari, View ORCID ProfileUttam Pal, Sayan Bayan, Susmita Mondal, Ria Ghosh, Soumendra Darbar, Tanusri Saha-Dasgupta, Samit Kumar Ray, Samir Kumar Pal
doi: https://doi.org/10.1101/2021.02.20.432081
Aniruddha Adhikari
1Department of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India
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  • ORCID record for Aniruddha Adhikari
Uttam Pal
2Technical Research Centre, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India
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Sayan Bayan
3Department of Condensed Matter Physics and Material Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India
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Susmita Mondal
1Department of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India
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Ria Ghosh
2Technical Research Centre, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India
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Soumendra Darbar
4Research & Development Division, Dey’s Medical Stores (Mfg.) Ltd, 62, Bondel Road, Ballygunge, Kolkata 700019, India
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Tanusri Saha-Dasgupta
2Technical Research Centre, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India
3Department of Condensed Matter Physics and Material Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India
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  • For correspondence: skpal@bose.res.in tanusri@bose.res.in samit@bose.res.in
Samit Kumar Ray
3Department of Condensed Matter Physics and Material Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India
5Department of Physics, Indian Institute of Technology Kharagpur, Kharagpur 721302, India
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  • For correspondence: skpal@bose.res.in tanusri@bose.res.in samit@bose.res.in
Samir Kumar Pal
1Department of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India
2Technical Research Centre, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India
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  • For correspondence: skpal@bose.res.in tanusri@bose.res.in samit@bose.res.in
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ABSTRACT

Centers for Disease Control and Prevention (CDC) warns the use of one-way valves or vents in free masks for potential threat of spreading COVID-19 through expelled respiratory droplets. Here, we have developed a nanoceutical cotton fabric duly sensitized with non-toxic zinc oxide nanomaterial for potential use as membrane filter in the one way valve for the ease of breathing without the threat of COVID-19 spreading. A detailed computational study revealed that zinc oxide nanoflowers (ZnO NF) with almost two-dimensional petals trap SARS-CoV-2 spike proteins, responsible to attach to ACE-2 receptors in human lung epithelial cells. The study also confirm significant denaturation of the spike proteins on the ZnO surface, revealing removal of virus upon efficient trapping. Following the computational study, we have synthesized ZnO NF on cotton matrix using hydrothermal assisted strategy. Electron microscopic, steady-state and picosecond resolved spectroscopic studies confirm attachment of ZnO NF to the cotton (i.e., cellulose) matrix at atomic level to develop the nanoceutical fabric. A detailed antimicrobial assay using Pseudomonas aeruginosa bacteria (model SARS-CoV-2 mimic) reveals excellent anti-microbial efficiency of the developed nanoceutical fabric. To our understanding the novel nanoceutical fabric used in one-way valve of a face mask would be the choice to assure breathing comfort along with source control of COVID-19 infection. The developed nanosensitized cloth can also be used as antibacterial/anti CoV-2 washable dress material in general.

Figure

GRAPHICAL ABSTRACTA novel nanoceutical cotton fabric duly sensitized with non-toxic zinc oxide nanoflower can potentially be used as membrane filter in the one way valve of face mask to assure breathing comfort along with source control of COVID-19 infection. The nanoceutical fabric denatures the SARS-CoV-2 spike protein and makes the microorganism ineffective.

Competing Interest Statement

The authors have declared no competing interest.

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Posted February 22, 2021.
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Nanoceutical Fabric Prevents COVID-19 Spread through Expelled Respiratory Droplets: A Combined Computational, Spectroscopic and Anti-microbial Study
Aniruddha Adhikari, Uttam Pal, Sayan Bayan, Susmita Mondal, Ria Ghosh, Soumendra Darbar, Tanusri Saha-Dasgupta, Samit Kumar Ray, Samir Kumar Pal
bioRxiv 2021.02.20.432081; doi: https://doi.org/10.1101/2021.02.20.432081
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Nanoceutical Fabric Prevents COVID-19 Spread through Expelled Respiratory Droplets: A Combined Computational, Spectroscopic and Anti-microbial Study
Aniruddha Adhikari, Uttam Pal, Sayan Bayan, Susmita Mondal, Ria Ghosh, Soumendra Darbar, Tanusri Saha-Dasgupta, Samit Kumar Ray, Samir Kumar Pal
bioRxiv 2021.02.20.432081; doi: https://doi.org/10.1101/2021.02.20.432081

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