Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Interaural Time Difference Tuning in the Rat Inferior Colliculus is Predictive of Behavioral Sensitivity

View ORCID ProfileKongyan Li, View ORCID ProfileVani G. Rajendran, View ORCID ProfileAmbika Prasad Mishra, Chloe H.K. Chan, View ORCID ProfileJan W. H. Schnupp
doi: https://doi.org/10.1101/2021.02.21.432131
Kongyan Li
1Department of Neuroscience, City University of Hong Kong, Hong Kong
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Kongyan Li
Vani G. Rajendran
1Department of Neuroscience, City University of Hong Kong, Hong Kong
3Laboratoire des systèmes perceptifs, Département d’études cognitives, École normale supérieure, PSL University, CNRS, 75005 Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Vani G. Rajendran
Ambika Prasad Mishra
1Department of Neuroscience, City University of Hong Kong, Hong Kong
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ambika Prasad Mishra
Chloe H.K. Chan
1Department of Neuroscience, City University of Hong Kong, Hong Kong
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jan W. H. Schnupp
1Department of Neuroscience, City University of Hong Kong, Hong Kong
2City University of Hong Kong Shenzhen Research Institute, Shenzhen, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jan W. H. Schnupp
  • For correspondence: wschnupp@cityu.edu.hk
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Data/Code
  • Preview PDF
Loading

Abstract

Recent studies have shown that rats are a useful model for binaural cochlear implant (CI) research, with behavioral sensitivity to interaural time differences (ITDs) of CI stimuli which are better than those of human patients. Here, we characterize ITD tuning in the rat inferior colliculus (IC) and explore whether quality of tuning can predict behavioral performance. We recorded IC responses to stimuli of varying pulse rates and envelope types and quantified both mutual information (MI) and neural d′ as measures of ITD sensitivity. Neural d′ values paralleled behavioral ones, declining with increasing click rates or when envelopes changed from rectangular to Hanning windows. While MI values increased with experience, neural d′ did not. However, neural d′ values correlated much better with behavioral performance than MI. Thus, neural d′ appears to be a particularly well suited to predicting how stimulus parameters will impact behavioral performance.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵* equal contribution

  • https://doi.org/10.5061/dryad.b5mkkwhcn

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
Back to top
PreviousNext
Posted February 28, 2021.
Download PDF
Data/Code
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Interaural Time Difference Tuning in the Rat Inferior Colliculus is Predictive of Behavioral Sensitivity
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Interaural Time Difference Tuning in the Rat Inferior Colliculus is Predictive of Behavioral Sensitivity
Kongyan Li, Vani G. Rajendran, Ambika Prasad Mishra, Chloe H.K. Chan, Jan W. H. Schnupp
bioRxiv 2021.02.21.432131; doi: https://doi.org/10.1101/2021.02.21.432131
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Interaural Time Difference Tuning in the Rat Inferior Colliculus is Predictive of Behavioral Sensitivity
Kongyan Li, Vani G. Rajendran, Ambika Prasad Mishra, Chloe H.K. Chan, Jan W. H. Schnupp
bioRxiv 2021.02.21.432131; doi: https://doi.org/10.1101/2021.02.21.432131

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4688)
  • Biochemistry (10379)
  • Bioengineering (7695)
  • Bioinformatics (26372)
  • Biophysics (13547)
  • Cancer Biology (10720)
  • Cell Biology (15460)
  • Clinical Trials (138)
  • Developmental Biology (8509)
  • Ecology (12842)
  • Epidemiology (2067)
  • Evolutionary Biology (16885)
  • Genetics (11416)
  • Genomics (15493)
  • Immunology (10638)
  • Microbiology (25254)
  • Molecular Biology (10239)
  • Neuroscience (54587)
  • Paleontology (402)
  • Pathology (1671)
  • Pharmacology and Toxicology (2899)
  • Physiology (4355)
  • Plant Biology (9263)
  • Scientific Communication and Education (1588)
  • Synthetic Biology (2561)
  • Systems Biology (6789)
  • Zoology (1470)