Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Extracellular Delivery of Functional Mitochondria Reverses the Dysfunction of CD4+ T Cells in Aging

View ORCID ProfileColwyn A. Headley, Shalini Gautam, Anwari Akhter, Varun Dwivedi, Russell Ault, Jordi B. Torrelles, Jonathan Gelfond, Joanne Turner
doi: https://doi.org/10.1101/2021.02.21.432151
Colwyn A. Headley
1Host Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA
2Biomedical Sciences Graduate Program, The Ohio State University, Columbus, Ohio 43201, USA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Colwyn A. Headley
Shalini Gautam
1Host Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anwari Akhter
3Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Varun Dwivedi
1Host Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Russell Ault
1Host Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA
2Biomedical Sciences Graduate Program, The Ohio State University, Columbus, Ohio 43201, USA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jordi B. Torrelles
3Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, 78227, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan Gelfond
4UT-Health San Antonio, Department of Epidemiology & Biostatistics, San Antonio, Texas 78229, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joanne Turner
1Host Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: joanneturner@txbiomed.org
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Mitochondrial dysfunction alters cellular metabolism, increases oxidative stress, and may be principal to the dysregulated signaling and function of CD4+ T lymphocytes in the elderly. Mitochondria influence adaptive immune responses through glucose and fatty acid metabolism, calcium buffering, and redox signaling. By transferring young mitochondria into CD4+ T cells from old mice, we investigated whether aging-associated mitochondrial dysfunction could be abrogated and whether such transfer changed CD4+ T cell function. Our results show that mitochondrial transfer improved the redox status and function of CD4+ T cells from old mice ex vivo. These findings support the notion that mitochondria can serve as targets of therapeutic intervention in aging.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
Back to top
PreviousNext
Posted February 21, 2021.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Extracellular Delivery of Functional Mitochondria Reverses the Dysfunction of CD4+ T Cells in Aging
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Extracellular Delivery of Functional Mitochondria Reverses the Dysfunction of CD4+ T Cells in Aging
Colwyn A. Headley, Shalini Gautam, Anwari Akhter, Varun Dwivedi, Russell Ault, Jordi B. Torrelles, Jonathan Gelfond, Joanne Turner
bioRxiv 2021.02.21.432151; doi: https://doi.org/10.1101/2021.02.21.432151
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Extracellular Delivery of Functional Mitochondria Reverses the Dysfunction of CD4+ T Cells in Aging
Colwyn A. Headley, Shalini Gautam, Anwari Akhter, Varun Dwivedi, Russell Ault, Jordi B. Torrelles, Jonathan Gelfond, Joanne Turner
bioRxiv 2021.02.21.432151; doi: https://doi.org/10.1101/2021.02.21.432151

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Immunology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4685)
  • Biochemistry (10362)
  • Bioengineering (7682)
  • Bioinformatics (26342)
  • Biophysics (13534)
  • Cancer Biology (10693)
  • Cell Biology (15446)
  • Clinical Trials (138)
  • Developmental Biology (8501)
  • Ecology (12824)
  • Epidemiology (2067)
  • Evolutionary Biology (16867)
  • Genetics (11401)
  • Genomics (15484)
  • Immunology (10619)
  • Microbiology (25225)
  • Molecular Biology (10225)
  • Neuroscience (54481)
  • Paleontology (402)
  • Pathology (1669)
  • Pharmacology and Toxicology (2897)
  • Physiology (4345)
  • Plant Biology (9252)
  • Scientific Communication and Education (1587)
  • Synthetic Biology (2558)
  • Systems Biology (6781)
  • Zoology (1466)