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Comparative Perturbation-Based Modeling of the SARS-CoV-2 Spike Protein Binding with Host Receptor and Neutralizing Antibodies : Structurally Adaptable Allosteric Communication Hotspots Define Spike Sites Targeted by Global Circulating Mutations

Gennady M. Verkhivker, Steve Agajanian, Deniz Yazar Oztas, Grace Gupta
doi: https://doi.org/10.1101/2021.02.21.432165
Gennady M. Verkhivker
1Keck Center for Science and Engineering, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, CA 92866, USA
2Depatment of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, CA 92618, USA
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  • For correspondence: verkhivk@chapman.edu
Steve Agajanian
1Keck Center for Science and Engineering, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, CA 92866, USA
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Deniz Yazar Oztas
1Keck Center for Science and Engineering, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, CA 92866, USA
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Grace Gupta
1Keck Center for Science and Engineering, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, CA 92866, USA
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Posted February 22, 2021.
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Comparative Perturbation-Based Modeling of the SARS-CoV-2 Spike Protein Binding with Host Receptor and Neutralizing Antibodies : Structurally Adaptable Allosteric Communication Hotspots Define Spike Sites Targeted by Global Circulating Mutations
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Comparative Perturbation-Based Modeling of the SARS-CoV-2 Spike Protein Binding with Host Receptor and Neutralizing Antibodies : Structurally Adaptable Allosteric Communication Hotspots Define Spike Sites Targeted by Global Circulating Mutations
Gennady M. Verkhivker, Steve Agajanian, Deniz Yazar Oztas, Grace Gupta
bioRxiv 2021.02.21.432165; doi: https://doi.org/10.1101/2021.02.21.432165
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Comparative Perturbation-Based Modeling of the SARS-CoV-2 Spike Protein Binding with Host Receptor and Neutralizing Antibodies : Structurally Adaptable Allosteric Communication Hotspots Define Spike Sites Targeted by Global Circulating Mutations
Gennady M. Verkhivker, Steve Agajanian, Deniz Yazar Oztas, Grace Gupta
bioRxiv 2021.02.21.432165; doi: https://doi.org/10.1101/2021.02.21.432165

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