Structural Basis for Accommodation of Emerging B.1.351 and B.1.1.7 Variants by Two Potent SARS-CoV-2 Neutralizing Antibodies

Gabriele Cerutti; Micah Rapp; Yicheng Guo; Fabiana Bahna; Jude Bimela; Eswar R. Reddem; Jian Yu; Pengfei Wang; Lihong Liu; Yaoxing Huang; David D. Ho; Peter D. Kwong; Zizhang Sheng; Lawrence Shapiro

doi:10.1101/2021.02.21.432168

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Structural Basis for Accommodation of Emerging B.1.351 and B.1.1.7 Variants by Two Potent SARS-CoV-2 Neutralizing Antibodies

View ORCID ProfileGabriele Cerutti, Micah Rapp, Yicheng Guo, Fabiana Bahna, Jude Bimela, Eswar R. Reddem, Jian Yu, Pengfei Wang, Lihong Liu, Yaoxing Huang, David D. Ho, Peter D. Kwong, Zizhang Sheng, Lawrence Shapiro

doi: https://doi.org/10.1101/2021.02.21.432168

Gabriele Cerutti

1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA

2Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10029, USA

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ORCID record for Gabriele Cerutti

Micah Rapp

1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA

2Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10029, USA

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Yicheng Guo

2Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10029, USA

3Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA

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Fabiana Bahna

1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA

2Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10029, USA

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Jude Bimela

1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA

2Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10029, USA

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Eswar R. Reddem

1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA

2Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10029, USA

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Jian Yu

3Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA

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Pengfei Wang

3Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA

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Lihong Liu

3Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA

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Yaoxing Huang

3Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA

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David D. Ho

3Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA

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Peter D. Kwong

1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA

4Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA

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Zizhang Sheng

3Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA

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For correspondence: zs2248@cumc.columbia.edu lss8@columbia.edu

Lawrence Shapiro

1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA

2Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10029, USA

3Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA

4Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA

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For correspondence: zs2248@cumc.columbia.edu lss8@columbia.edu

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Structural Basis for Accommodation of Emerging B.1.351 and B.1.1.7 Variants by Two Potent SARS-CoV-2 Neutralizing Antibodies

Gabriele Cerutti, Micah Rapp, Yicheng Guo, Fabiana Bahna, Jude Bimela, Eswar R. Reddem, Jian Yu, Pengfei Wang, Lihong Liu, Yaoxing Huang, David D. Ho, Peter D. Kwong, Zizhang Sheng, Lawrence Shapiro

bioRxiv 2021.02.21.432168; doi: https://doi.org/10.1101/2021.02.21.432168

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Structural Basis for Accommodation of Emerging B.1.351 and B.1.1.7 Variants by Two Potent SARS-CoV-2 Neutralizing Antibodies

Gabriele Cerutti, Micah Rapp, Yicheng Guo, Fabiana Bahna, Jude Bimela, Eswar R. Reddem, Jian Yu, Pengfei Wang, Lihong Liu, Yaoxing Huang, David D. Ho, Peter D. Kwong, Zizhang Sheng, Lawrence Shapiro

bioRxiv 2021.02.21.432168; doi: https://doi.org/10.1101/2021.02.21.432168

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