Astrocyte-derived TNF and glutamate critically modulate microglia reactivity by methamphetamine

Teresa Canedo; Camila Cabral Portugal; Renato Socodato; Joana Bravo; Tiago Oliveira Almeida; João D. Magalhães; Sónia Guerra-Gomes; João Filipe Oliveira; Nuno Sousa; Ana Magalhães; João Bettencourt Relvas; Teresa Summavielle

doi:10.1101/2021.02.22.432170

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Astrocyte-derived TNF and glutamate critically modulate microglia reactivity by methamphetamine

View ORCID ProfileTeresa Canedo, View ORCID ProfileCamila Cabral Portugal, View ORCID ProfileRenato Socodato, View ORCID ProfileJoana Bravo, Tiago Oliveira Almeida, João D. Magalhães, View ORCID ProfileSónia Guerra-Gomes, View ORCID ProfileJoão Filipe Oliveira, View ORCID ProfileNuno Sousa, View ORCID ProfileAna Magalhães, View ORCID ProfileJoão Bettencourt Relvas, View ORCID ProfileTeresa Summavielle

doi: https://doi.org/10.1101/2021.02.22.432170

Teresa Canedo

1Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Portugal.

2Faculdade de Medicina da Universidade do Porto (FMUP), Portugal.

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Camila Cabral Portugal

3Glial Cell Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Portugal.

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For correspondence: tsummavi@ibmc.up.pt

Renato Socodato

3Glial Cell Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Portugal.

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Joana Bravo

1Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Portugal.

4Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, Portugal

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Tiago Oliveira Almeida

3Glial Cell Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Portugal.

4Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, Portugal

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João D. Magalhães

1Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Portugal.

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Sónia Guerra-Gomes

5Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Portugal.

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João Filipe Oliveira

5Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Portugal.

6ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal

7IPCA-EST-2Ai, Polytechnic Institute of Cávado and Ave, Applied Artificial Intelligence

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Nuno Sousa

5Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Portugal.

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Ana Magalhães

1Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Portugal.

4Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, Portugal

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João Bettencourt Relvas

2Faculdade de Medicina da Universidade do Porto (FMUP), Portugal.

3Glial Cell Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Portugal.

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Teresa Summavielle

1Addiction Biology Group, i3S-Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Portugal.

8ESS.PP, Escola Superior de Saúde do Politécnico do Porto, Portugal

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For correspondence: tsummavi@ibmc.up.pt

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Astrocyte-derived TNF and glutamate critically modulate microglia reactivity by methamphetamine

Teresa Canedo, Camila Cabral Portugal, Renato Socodato, Joana Bravo, Tiago Oliveira Almeida, João D. Magalhães, Sónia Guerra-Gomes, João Filipe Oliveira, Nuno Sousa, Ana Magalhães, João Bettencourt Relvas, Teresa Summavielle

bioRxiv 2021.02.22.432170; doi: https://doi.org/10.1101/2021.02.22.432170

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