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Age and Race related changes in Gene Expression during Human PBMC aging

Yang Hu, Yudai Xu, Wen Lei, Jian Xiang, Lipeng Mao, Guobing Chen
doi: https://doi.org/10.1101/2021.02.22.432179
Yang Hu
1Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China
2Department of Neurology, the First Affiliated Hospital, Jinan University, Guangzhou, China
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Yudai Xu
1Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China
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Wen Lei
1Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China
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Jian Xiang
1Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China
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Lipeng Mao
1Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China
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Guobing Chen
1Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China
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  • For correspondence: guobingchen@jnu.edu.cn
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Abstract

Human immune system functions over an entire lifetime, yet how and why the immune system becomes less effective with age are not well understood. Here, we characterize peripheral blood mononuclear cells from 172 healthy adults 21~90 years of age using RNA-seq and the weighted gene correlation network analysis (WGCNA). These data have revealed a meaningful of gene expression modules or representative biomarkers for human immune system aging in Aisan and White ancestry. Among them, several gene modules demonstrated a remarkably correlation with human immune aging progress. Besides, further analysis on these ageing related modules show age-related gene expression changes spike is around early-seventies. More importantly, we also focus on how race and ethnicity affect immune aging as race-specific effects on these gene expression changes have clinical applications for diagnosis and interpretation of immunosenescence. Thus, the top hub genes including NUDT7, CLPB, OXNAD1 and MLLT3 are identified from Asian and white aging related modules and further validated in humans PBMC at different ages. Finally, the impact of age and race on immune phenotypes we discuss may provide insights into future studies.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted February 22, 2021.
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Age and Race related changes in Gene Expression during Human PBMC aging
Yang Hu, Yudai Xu, Wen Lei, Jian Xiang, Lipeng Mao, Guobing Chen
bioRxiv 2021.02.22.432179; doi: https://doi.org/10.1101/2021.02.22.432179
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Age and Race related changes in Gene Expression during Human PBMC aging
Yang Hu, Yudai Xu, Wen Lei, Jian Xiang, Lipeng Mao, Guobing Chen
bioRxiv 2021.02.22.432179; doi: https://doi.org/10.1101/2021.02.22.432179

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