Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells

Emi Sano; Ayaka Sakamoto; Natsumi Mimura; Ai Hirabayashi; Yukiko Muramoto; Takeshi Noda; Takuya Yamamoto; Kazuo Takayama

doi:10.1101/2021.02.22.432218

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Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells

Emi Sano, Ayaka Sakamoto, Natsumi Mimura, Ai Hirabayashi, Yukiko Muramoto, Takeshi Noda, Takuya Yamamoto, Kazuo Takayama

doi: https://doi.org/10.1101/2021.02.22.432218

Emi Sano

1Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan

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Ayaka Sakamoto

1Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan

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Natsumi Mimura

1Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan

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Ai Hirabayashi

2Laboratory of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan

3CREST, Japan Science and Technology Agency (JST), Kawaguchi 332-0012, Japan

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Yukiko Muramoto

2Laboratory of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan

3CREST, Japan Science and Technology Agency (JST), Kawaguchi 332-0012, Japan

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Takeshi Noda

2Laboratory of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan

3CREST, Japan Science and Technology Agency (JST), Kawaguchi 332-0012, Japan

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Takuya Yamamoto

1Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan

4Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto 606-8501 Japan

5Medical-risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto 606-8507, Japan

6AMED-CREST, Japan Agency for Medical Research and Development (AMED), Tokyo 100-0004, Japan

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Kazuo Takayama

1Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan

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For correspondence: kazuo.takayama@cira.kyoto-u.ac.jp

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Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells

Emi Sano, Ayaka Sakamoto, Natsumi Mimura, Ai Hirabayashi, Yukiko Muramoto, Takeshi Noda, Takuya Yamamoto, Kazuo Takayama

bioRxiv 2021.02.22.432218; doi: https://doi.org/10.1101/2021.02.22.432218

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Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells

Emi Sano, Ayaka Sakamoto, Natsumi Mimura, Ai Hirabayashi, Yukiko Muramoto, Takeshi Noda, Takuya Yamamoto, Kazuo Takayama

bioRxiv 2021.02.22.432218; doi: https://doi.org/10.1101/2021.02.22.432218

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